Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3083
MIM: 604552
HGNC: 4894
Ensembl: ENSG00000109758
Variants:
dbSNP: 3083
ClinVar: 3083
TCGA: ENSG00000109758
COSMIC: HGFAC
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000109758 | ENST00000382774 | Q04756 |
| ENSG00000109758 | ENST00000511533 | D6RAR4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by MET | REACTOME | R-HSA-6806834 |
| MET Receptor Activation | REACTOME | R-HSA-6806942 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444418 | Gastrointestinal Hemorrhage | Disease | Literature, MultilinkAnnotation | associated | 24949630 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36413406 | 2023 | HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. | 5 |
| 38077422 | 2023 | miR-4270 suppresses hepatocellular carcinoma progression by inhibiting DNMT3A-mediated methylation of HGFAC promoter. | 1 |
| 36413406 | 2023 | HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. | 5 |
| 38077422 | 2023 | miR-4270 suppresses hepatocellular carcinoma progression by inhibiting DNMT3A-mediated methylation of HGFAC promoter. | 1 |
| 36182093 | 2022 | Role of hypoxia on microRNA-dependant regulation of HGFA - HGF - c-Met signalling pathway in human progenitor and mature endothelial cells. | 1 |
| 36182093 | 2022 | Role of hypoxia on microRNA-dependant regulation of HGFA - HGF - c-Met signalling pathway in human progenitor and mature endothelial cells. | 1 |
| 30635948 | 2019 | HGFAC expression decreased in liver cancer and its low expression correlated with DNA hypermethylation and poor prognosis. | 4 |
| 30635948 | 2019 | HGFAC expression decreased in liver cancer and its low expression correlated with DNA hypermethylation and poor prognosis. | 4 |
| 25998175 | 2015 | Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA). | 9 |
| 25998175 | 2015 | Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA). | 9 |
| 20424473 | 2010 | L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. | 0 |
| 20424473 | 2010 | L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. | 0 |
| 19456860 | 2009 | Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein. | 13 |
| 19456860 | 2009 | Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein. | 13 |
| 18221492 | 2008 | Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases. | 24 |
Citation
Dessen P
HGFAC (HGF activator)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46296/hgfac
