Identity
HGNC
LOCATION
16q12.2
LOCUSID
ALIAS
NAT1,NET,NET1,SLC6A5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6530
MIM: 163970
HGNC: 11048
Ensembl: ENSG00000103546
Variants:
dbSNP: 6530
ClinVar: 6530
TCGA: ENSG00000103546
COSMIC: SLC6A2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131887008 | 3,4-methylenedioxymethamphetamine | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | |||
| PA134688071 | atomoxetine | Chemical | ClinicalAnnotation | associated | PD | 19387424, 23266789 | |
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation | associated | PD | 19387424, 23083021, 23266789, 23609393, 29230023, 29374517 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 28068779 | |
| PA449233 | desipramine | Chemical | Pathway | associated | |||
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation | associated | PD | 23083021, 23609393, 29230023, 29374517 | |
| PA451866 | venlafaxine | Chemical | ClinicalAnnotation | associated | PD | 28068779 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38166870 | 2024 | Relationship between SLC6A2 gene polymorphisms and brain volume in Han Chinese adults who lost their sole child. | 0 |
| 38750358 | 2024 | Dimerization and antidepressant recognition at noradrenaline transporter. | 0 |
| 38166870 | 2024 | Relationship between SLC6A2 gene polymorphisms and brain volume in Han Chinese adults who lost their sole child. | 0 |
| 38750358 | 2024 | Dimerization and antidepressant recognition at noradrenaline transporter. | 0 |
| 36774338 | 2023 | Genotype-by-diagnosis interaction influences self-control in human cocaine addiction. | 0 |
| 36774338 | 2023 | Genotype-by-diagnosis interaction influences self-control in human cocaine addiction. | 0 |
| 31383926 | 2021 | Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity-impulsivity symptoms in ADHD measured with PET. | 14 |
| 31595036 | 2021 | The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder. | 12 |
| 33104153 | 2021 | Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study. | 1 |
| 33340618 | 2021 | Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder. | 2 |
| 33529804 | 2021 | Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells. | 1 |
| 34112854 | 2021 | Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors. | 6 |
| 34203885 | 2021 | Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population. | 0 |
| 34445205 | 2021 | The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia. | 3 |
| 31383926 | 2021 | Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity-impulsivity symptoms in ADHD measured with PET. | 14 |
Citation
Dessen P
SLC6A2 (solute carrier family 6 member 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46297/slc6a2
