ARPC1B (actin related protein 2/3 complex subunit 1B)

2007-02-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
ARC41,IMD71,PLTEID,p40-ARC,p41-ARC
FUSION GENES

Other Information

Locus ID:

NCBI: 10095
MIM: 604223
HGNC: 704
Ensembl: ENSG00000130429

Variants:

dbSNP: 10095
ClinVar: 10095
TCGA: ENSG00000130429
COSMIC: ARPC1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130429ENST00000414376C9JBJ7
ENSG00000130429ENST00000417330C9JEY1
ENSG00000130429ENST00000418347C9JTT6
ENSG00000130429ENST00000427217O15143
ENSG00000130429ENST00000427217A4D275
ENSG00000130429ENST00000429246C9JM51
ENSG00000130429ENST00000431816O15143
ENSG00000130429ENST00000431816A4D275
ENSG00000130429ENST00000432343F8VXW2
ENSG00000130429ENST00000443222C9K057
ENSG00000130429ENST00000445924F8WEB3
ENSG00000130429ENST00000451682O15143
ENSG00000130429ENST00000451682A4D275
ENSG00000130429ENST00000455009O15143
ENSG00000130429ENST00000455009A4D275
ENSG00000130429ENST00000458033O15143
ENSG00000130429ENST00000458033A4D275
ENSG00000130429ENST00000645391O15143
ENSG00000130429ENST00000645391A4D275
ENSG00000130429ENST00000646101O15143
ENSG00000130429ENST00000646101A4D275

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382241392024Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B.2
384859072024Description of a Novel Pathogenic Variant in the ARPC1B and a Severe Allergy in Two Infants.0
382241392024Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B.2
384859072024Description of a Novel Pathogenic Variant in the ARPC1B and a Severe Allergy in Two Infants.0
351113862022Dual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastoma.9
351633982022ARPC1B Is Associated with Lethal Prostate Cancer and Its Inhibition Decreases Cell Invasion and Migration In Vitro.5
359673032022Radiosensitivity in patients affected by ARPC1B deficiency: a new disease trait?2
363803682022ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells.13
351113862022Dual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastoma.9
351633982022ARPC1B Is Associated with Lethal Prostate Cancer and Its Inhibition Decreases Cell Invasion and Migration In Vitro.5
359673032022Radiosensitivity in patients affected by ARPC1B deficiency: a new disease trait?2
363803682022ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells.13
327745612020DHX36, BAX, and ARPC1B May Be Critical for the Diagnosis and Treatment of Tuberculosis.2
327745612020DHX36, BAX, and ARPC1B May Be Critical for the Diagnosis and Treatment of Tuberculosis.2
313798352019Flow Cytometric Determination of Actin Polymerization in Peripheral Blood Leukocytes Effectively Discriminate Patients With Homozygous Mutation in ARPC1B From Asymptomatic Carriers and Normal Controls.9

Citation

Dessen P

ARPC1B (actin related protein 2/3 complex subunit 1B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46311/arpc1b