IL1RL1 (interleukin 1 receptor like 1)

2007-02-01  

Identity

HGNC
IL1RL1
LOCATION
2q12.1
LOCUSID
9173
ALIAS
DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

Other Information

Locus ID:

NCBI: 9173
MIM: 601203
HGNC: 5998
Ensembl: ENSG00000115602

Variants:

dbSNP: 9173
ClinVar: 9173
TCGA: ENSG00000115602
COSMIC: IL1RL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115602ENST00000233954Q01638
ENSG00000115602ENST00000311734Q01638
ENSG00000115602ENST00000404917Q01638
ENSG00000115602ENST00000409584E9PC41
ENSG00000115602ENST00000427077Q01638
ENSG00000115602ENST00000447231C9JSY6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
381722582024A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.0
388587402024The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial-mesenchymal transition by phosphorylating β-catenin.0
381722582024A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.0
388587402024The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial-mesenchymal transition by phosphorylating β-catenin.0
369475652023Single nucleotide variants in the IL33 and IL1RL1 (ST2) genes are associated with periodontitis and with Aggregatibacter actinomycetemcomitans in the dental plaque biofilm: A putative role in understanding the host immune response in periodontitis.0
374425822023Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.6
376432442023IL-33-ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways.3
369475652023Single nucleotide variants in the IL33 and IL1RL1 (ST2) genes are associated with periodontitis and with Aggregatibacter actinomycetemcomitans in the dental plaque biofilm: A putative role in understanding the host immune response in periodontitis.0
374425822023Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.6
376432442023IL-33-ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways.3
347414822022Interleukin 1 receptor-like 1 rs13408661/13431828 polymorphism is associated with persistent post-bronchiolitis asthma at school age.3
350673872022The function of IL-33/ST2 signaling axis in treg cells activating fibrosis in IgG4-related disease.1
351592242022Soluble ST2 Receptor: Biomarker of Left Ventricular Impairment and Functional Status in Patients with Inflammatory Cardiomyopathy.6
351889952022Suppression of tumorigenicity-2 (ST2) is a promising biomarker in heart transplantation.3
352784592022Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fraction.3

Citation

Dessen P

IL1RL1 (interleukin 1 receptor like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46331