MYO6 (myosin VI)

2007-02-01  

Identity

HGNC
MYO6
LOCATION
6q14.1
LOCUSID
4646
ALIAS
DFNA22,DFNB37
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4646
MIM: 600970
HGNC: 7605
Ensembl: ENSG00000196586

Variants:

dbSNP: 4646
ClinVar: 4646
TCGA: ENSG00000196586
COSMIC: MYO6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196586ENST00000369975A0A0A0MRM8
ENSG00000196586ENST00000369977Q9UM54
ENSG00000196586ENST00000369981E7EW20
ENSG00000196586ENST00000369985Q9UM54
ENSG00000196586ENST00000430435Q5JVM0
ENSG00000196586ENST00000462633A0A590UJW9
ENSG00000196586ENST00000615563Q9UM54
ENSG00000196586ENST00000627432A0A0D9SGC1
ENSG00000196586ENST00000653423A0A590UK22
ENSG00000196586ENST00000653917A0A590UJY4
ENSG00000196586ENST00000660420A0A590UJ48
ENSG00000196586ENST00000662184A0A590UK71
ENSG00000196586ENST00000662603A0A590UJ75
ENSG00000196586ENST00000663400A0A590UK86
ENSG00000196586ENST00000664209A0A590UKB0
ENSG00000196586ENST00000664640A0A590UJ40
ENSG00000196586ENST00000672093A0A1Y0BRN3

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Gap junction trafficking and regulationREACTOMER-HSA-157858
Gap junction traffickingREACTOMER-HSA-190828
Gap junction degradationREACTOMER-HSA-190873

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378721462023How myosin VI traps its off-state, is activated and dimerizes.0
378721462023How myosin VI traps its off-state, is activated and dimerizes.0
333720342021Dynamic multimerization of Dab2-Myosin VI complexes regulates cargo processivity while minimizing cortical actin reorganization.6
342378992021A dynamic Dab2 keeps myosin VI stably on track.0
342382132021LncRNA UCA1 promotes development of gastric cancer via the miR-145/MYO6 axis.15
333720342021Dynamic multimerization of Dab2-Myosin VI complexes regulates cargo processivity while minimizing cortical actin reorganization.6
342378992021A dynamic Dab2 keeps myosin VI stably on track.0
342382132021LncRNA UCA1 promotes development of gastric cancer via the miR-145/MYO6 axis.15
317448802020Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function.12
320664202020Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss.0
321432902020Clinical Characteristics and In Vitro Analysis of MYO6 Variants Causing Late-Onset Progressive Hearing Loss.8
317448802020Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function.12
320664202020Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss.0
321432902020Clinical Characteristics and In Vitro Analysis of MYO6 Variants Causing Late-Onset Progressive Hearing Loss.8
303873752019MicroRNA-5195-3p plays a suppressive role in cell proliferation, migration and invasion by targeting MYO6 in human non-small cell lung cancer.15

Citation

Dessen P

MYO6 (myosin VI)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46347/teaching-explorer/css/lib/bootstrap.min.css