PITX1 (paired like homeodomain 1)

2007-02-01  

Identity

HGNC
PITX1
LOCATION
5q31.1
LOCUSID
5307
ALIAS
BFT,CCF,LBNBG,POTX,PTX1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5307
MIM: 602149
HGNC: 9004
Ensembl: ENSG00000069011

Variants:

dbSNP: 5307
ClinVar: 5307
TCGA: ENSG00000069011
COSMIC: PITX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069011ENST00000265340P78337
ENSG00000069011ENST00000265340X5D9A5
ENSG00000069011ENST00000502676D6R955
ENSG00000069011ENST00000506438P78337
ENSG00000069011ENST00000506438X5D9A5
ENSG00000069011ENST00000507253D6R9U1

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363342212023PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization.2
363342212023PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization.2
363601952022What Is the Exact Contribution of PITX1 and TBX4 Genes in Clubfoot Development? An Italian Study.2
363601952022What Is the Exact Contribution of PITX1 and TBX4 Genes in Clubfoot Development? An Italian Study.2
337638402021CircPITX1 Regulates Proliferation, Angiogenesis, Migration, Invasion, and Cell Cycle of Human Glioblastoma Cells by Targeting miR-584-5p/KPNB1 Axis.8
342152212021Differential gene expression identifies a transcriptional regulatory network involving ER-alpha and PITX1 in invasive epithelial ovarian cancer.3
345266092021PITX1 inhibits the growth and proliferation of melanoma cells through regulation of SOX family genes.5
348683972021Upregulated Transcription Factor PITX1 Predicts Poor Prognosis in Kidney Renal Clear Cell Carcinoma-Based Bioinformatic Analysis and Experimental Verification.1
337638402021CircPITX1 Regulates Proliferation, Angiogenesis, Migration, Invasion, and Cell Cycle of Human Glioblastoma Cells by Targeting miR-584-5p/KPNB1 Axis.8
342152212021Differential gene expression identifies a transcriptional regulatory network involving ER-alpha and PITX1 in invasive epithelial ovarian cancer.3
345266092021PITX1 inhibits the growth and proliferation of melanoma cells through regulation of SOX family genes.5
348683972021Upregulated Transcription Factor PITX1 Predicts Poor Prognosis in Kidney Renal Clear Cell Carcinoma-Based Bioinformatic Analysis and Experimental Verification.1
325181742020Rare and de novo duplications containing SHOX in clubfoot.6
325985102020Mandibular-pelvic-patellar syndrome is a novel PITX1-related disorder due to alteration of PITX1 transactivation ability.1
327591682020The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene.8

Citation

Dessen P

PITX1 (paired like homeodomain 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46355