Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7099
MIM: 603030
HGNC: 11850
Ensembl: ENSG00000136869
Variants:
dbSNP: 7099
ClinVar: 7099
TCGA: ENSG00000136869
COSMIC: TLR4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136869 | ENST00000355622 | O00206 |
| ENSG00000136869 | ENST00000394487 | O00206 |
| ENSG00000136869 | ENST00000472304 | A0A2R8Y7P4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA133888799 | Organ Transplantation | Disease | ClinicalAnnotation | associated | PK | 24820765 | |
| PA164713160 | Pertussis vaccines | Chemical | ClinicalAnnotation | associated | PD | 17699831, 22383676 | |
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 24776844 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 20136356 | |
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 12742999 | |
| PA446116 | Inflammatory Bowel Diseases | Disease | ClinicalAnnotation | associated | PD | 24776844 | |
| PA449692 | folic acid | Chemical | ClinicalAnnotation | associated | PD | 20136356 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PD | 20136356 | |
| PA451089 | pravastatin | Chemical | ClinicalAnnotation | associated | PD | 12742999 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PK | 24820765 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34246209 | 2024 | The relationship between the rs4986791 variant of the TLR4 gene and the severity of bronchial asthma in children. | 0 |
| 36585554 | 2024 | Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-κB pathway. | 3 |
| 37150251 | 2024 | LPS-TLR4 pathway exaggerates alcoholic hepatitis via provoking NETs formation. | 1 |
| 37462743 | 2024 | Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study. | 0 |
| 37671668 | 2024 | Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14. | 1 |
| 37691112 | 2024 | Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy. | 5 |
| 37718198 | 2024 | Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia. | 0 |
| 37849336 | 2024 | Association of Toll-like receptor 4 gene polymorphism with multiple sclerosis in Iranian patients. | 0 |
| 37885279 | 2024 | Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2. | 2 |
| 37937521 | 2024 | Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study. | 0 |
| 37977066 | 2024 | The expression of Nrf2 and TLRs in ear effusion in children with different types of otitis media and their relationship with inflammatory factors. | 0 |
| 37994415 | 2024 | Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments. | 0 |
| 38029833 | 2024 | Variant rs4986790 of toll-like receptor 4 affects the signaling and induces cell dysfunction in patients with severe COVID-19. | 0 |
| 38103365 | 2024 | P53 and TLR4 expression are prognostic markers informing progression free survival of advanced stage high grade serous ovarian cancer. | 0 |
| 38195088 | 2024 | Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent. | 0 |
Citation
Dessen P
TLR4 (toll like receptor 4)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46368/tlr4
