WIPI1 (WD repeat domain, phosphoinositide interacting 1)

2007-02-01  

Identity

HGNC
WIPI1
LOCATION
17q24.2
LOCUSID
55062
ALIAS
ATG18,ATG18A,WIPI49
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55062
MIM: 609224
HGNC: 25471
Ensembl: ENSG00000070540

Variants:

dbSNP: 55062
ClinVar: 55062
TCGA: ENSG00000070540
COSMIC: WIPI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070540ENST00000262139Q5MNZ9
ENSG00000070540ENST00000546360G5EA37
ENSG00000070540ENST00000585393K7EKC5
ENSG00000070540ENST00000589316K7EK57
ENSG00000070540ENST00000591744K7ELY0
ENSG00000070540ENST00000592645K7EKN0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376203932023The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension.1
376203932023The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension.1
336362942021WIPI1 promotes osteosarcoma cell proliferation by inhibiting CDKN1A.8
336853632021WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms.18
346890102021WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.1
336362942021WIPI1 promotes osteosarcoma cell proliferation by inhibiting CDKN1A.8
336853632021WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms.18
346890102021WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.1
310218182019WIPI1 is a conserved mediator of right ventricular failure.16
310218182019WIPI1 is a conserved mediator of right ventricular failure.16
306226612018WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.37
306226612018WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.37
254625582015Fluorescence-based imaging of autophagy progression by human WIPI protein detection.8
254625582015Fluorescence-based imaging of autophagy progression by human WIPI protein detection.8
243845612014Detection of WIPI1 mRNA as an indicator of autophagosome formation.40

Citation

Dessen P

WIPI1 (WD repeat domain, phosphoinositide interacting 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46381/gene-fusions-explorer/haematological-explorer/