WIPI1 (WD repeat domain, phosphoinositide interacting 1)

2007-02-01  

Identity

HGNC
LOCATION
17q24.2
LOCUSID
ALIAS
ATG18,ATG18A,WIPI49
FUSION GENES

Other Information

Locus ID:

NCBI: 55062
MIM: 609224
HGNC: 25471
Ensembl: ENSG00000070540

Variants:

dbSNP: 55062
ClinVar: 55062
TCGA: ENSG00000070540
COSMIC: WIPI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070540ENST00000262139Q5MNZ9
ENSG00000070540ENST00000546360G5EA37
ENSG00000070540ENST00000585393K7EKC5
ENSG00000070540ENST00000589316K7EK57
ENSG00000070540ENST00000591744K7ELY0
ENSG00000070540ENST00000592645K7EKN0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376203932023The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension.1
376203932023The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension.1
336362942021WIPI1 promotes osteosarcoma cell proliferation by inhibiting CDKN1A.8
336853632021WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms.18
346890102021WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.1
336362942021WIPI1 promotes osteosarcoma cell proliferation by inhibiting CDKN1A.8
336853632021WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms.18
346890102021WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.1
310218182019WIPI1 is a conserved mediator of right ventricular failure.16
310218182019WIPI1 is a conserved mediator of right ventricular failure.16
306226612018WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.37
306226612018WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.37
254625582015Fluorescence-based imaging of autophagy progression by human WIPI protein detection.8
254625582015Fluorescence-based imaging of autophagy progression by human WIPI protein detection.8
243845612014Detection of WIPI1 mRNA as an indicator of autophagosome formation.40

Citation

Dessen P

WIPI1 (WD repeat domain, phosphoinositide interacting 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46381/gene-fusions-explorer/haematological-explorer/