HTR2A (5-hydroxytryptamine receptor 2A)

2007-02-01  

Identity

HGNC
HTR2A
LOCATION
13q14.2
LOCUSID
3356
ALIAS
5-HT2A,HTR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3356
MIM: 182135
HGNC: 5293
Ensembl: ENSG00000102468

Variants:

dbSNP: 3356
ClinVar: 3356
TCGA: ENSG00000102468
COSMIC: HTR2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102468ENST00000378688P28223
ENSG00000102468ENST00000542664P28223
ENSG00000102468ENST00000543956P28223
ENSG00000102468ENST00000612998A0A087WZJ9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Gap junctionKEGGko04540
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Gap junctionKEGGhsa04540
Serotonergic synapseKEGGhsa04726
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD19365399
PA124CYP2C19GeneDataAnnotationassociated
PA128CYP2D6GeneDataAnnotationassociated
PA128406954Weight gainDiseaseClinicalAnnotationassociatedPD19193342
PA164712362AnalgesicsChemicalClinicalAnnotationassociatedPD25096645
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociatedPD25096645
PA164712741Ergot alkaloidsChemicalClinicalAnnotationassociatedPD25096645
PA164713257Selective serotonin reuptake inhibitorsChemicalLiterature, MultilinkAnnotationassociated24930681
PA174GNAQGenePathwayassociated19741567
PA27093CYP1A2GeneDataAnnotationassociated
PA312SLC6A4GeneDataAnnotationassociated
PA443319Alzheimer DiseaseDiseaseClinicalAnnotationassociatedPD19494443
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD23859574
PA445048NauseaDiseaseClinicalAnnotationassociatedPD30221791
PA446051VomitingDiseaseClinicalAnnotationassociatedPD30221791
PA447196Anxiety DisordersDiseaseClinicalAnnotationassociatedPD22006095
PA447198Autistic DisorderDiseaseClinicalAnnotation, MultilinkAnnotationassociatedPD19997080, 24753316
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD17671280, 19365399, 19590397, 23158458
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD27272046
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD19000940, 19193342, 32462699
PA447230HIV InfectionsDiseaseClinicalAnnotationassociatedPD23859571
PA447268tardive dyskinesiaDiseaseClinicalAnnotationassociatedPD17688403
PA447278DepressionDiseaseClinicalAnnotation, DataAnnotationassociatedPD14514498, 17671280, 17697394, 18253134, 19590397
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotation, DataAnnotationassociatedPD11311507, 16205777, 16874005, 18253134, 19361869, 20075642, 22947179, 23733030, 25108775, 30221791
PA448687bupropionChemicalClinicalAnnotationassociatedPD22947179
PA449015citalopramChemicalClinicalAnnotationassociatedPD17671280, 19590397, 23158458, 30221791
PA449061clozapineChemicalLiterature, MultilinkAnnotationassociated24885933
PA449441efavirenzChemicalClinicalAnnotationassociatedPD23859571
PA449690fluvoxamineChemicalClinicalAnnotationassociatedPD16205777, 16874005, 19361869
PA450688olanzapineChemicalClinicalAnnotation, Literature, MultilinkAnnotationassociatedPD19000940, 19193342, 19494443, 19636338, 24885933, 32462699
PA450801paroxetineChemicalClinicalAnnotationassociatedPD14514498, 17697394, 18253134, 19361869
PA451257risperidoneChemicalClinicalAnnotationassociatedPD19494443, 19997080, 23859574, 32462699
PA451566sumatriptanChemicalClinicalAnnotationassociatedPD25096645
PA451866venlafaxineChemicalClinicalAnnotationassociatedPD22006095
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD11311507, 18253134, 20075642, 23733030, 25108775
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD17688403, 27272046
PA452618opioidsChemicalClinicalAnnotationassociatedPD25096645

References

Pubmed IDYearTitleCitations
377033102024A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex.0
385659882024Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study.0
386571232024The Association Between the 5-Hydroxytryptamine Receptor 2A Gene Variants rs6311 and rs6313 and Obstructive Sleep Apnea in the Iranian Kurdish Population.0
386621112024Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint.0
388115672024G protein-specific mechanisms in the serotonin 5-HT(2A) receptor regulate psychosis-related effects and memory deficits.0
377033102024A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex.0
385659882024Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study.0
386571232024The Association Between the 5-Hydroxytryptamine Receptor 2A Gene Variants rs6311 and rs6313 and Obstructive Sleep Apnea in the Iranian Kurdish Population.0
386621112024Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint.0
388115672024G protein-specific mechanisms in the serotonin 5-HT(2A) receptor regulate psychosis-related effects and memory deficits.0
347898572023His452Tyr 5-HT(2A) polymorphism and intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation.1
366395222023The contribution of the 5-hydroxytryptamine receptor 2 A gene polymorphisms rs6311 and rs6313 to Schizophrenia in Iran.2
367692902023Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development.2
368894322023The crosstalk between 5-HT(2A)R and mGluR2 in schizophrenia.7
370193192023Association of GABRG3, GABRB3, HTR2A gene variants with autism spectrum disorder.1

Citation

Dessen P

HTR2A (5-hydroxytryptamine receptor 2A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46384