CCT3 (chaperonin containing TCP1 subunit 3)

2007-02-01  

Identity

HGNC
CCT3
LOCATION
1q22
LOCUSID
7203
ALIAS
CCT-gamma,CCTG,PIG48,TCP-1-gamma,TRIC5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7203
MIM: 600114
HGNC: 1616
Ensembl: ENSG00000163468

Variants:

dbSNP: 7203
ClinVar: 7203
TCGA: ENSG00000163468
COSMIC: CCT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163468ENST00000295688P49368
ENSG00000163468ENST00000368258E9PRN0
ENSG00000163468ENST00000368259P49368
ENSG00000163468ENST00000368262E9PRM9
ENSG00000163468ENST00000413555Q5SZX6
ENSG00000163468ENST00000415548Q5SZX9
ENSG00000163468ENST00000446905Q5SZW8
ENSG00000163468ENST00000472765B4DUR8
ENSG00000163468ENST00000478640E9PM09
ENSG00000163468ENST00000496684E9PRC8
ENSG00000163468ENST00000533194E9PQ35

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Folding of actin by CCT/TriCREACTOMER-HSA-390450
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383600742024Dysfunction of CCT3-associated network signals for the critical state during progression of hepatocellular carcinoma.0
383600742024Dysfunction of CCT3-associated network signals for the critical state during progression of hepatocellular carcinoma.0
369188012023Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma.0
370923052023m(6)A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression.5
378336212023Circular RNA CCT3 is a unique molecular marker in bladder cancer.0
369188012023Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma.0
370923052023m(6)A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression.5
378336212023Circular RNA CCT3 is a unique molecular marker in bladder cancer.0
357736232022Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma.8
357736232022Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma.8
335084242021CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers.13
345056282021Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma.9
346127682021Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway.12
346516642021Upregulation of CCT3 promotes cervical cancer progression through FN1.10
335084242021CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers.13

Citation

Dessen P

CCT3 (chaperonin containing TCP1 subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46436