GHSR (growth hormone secretagogue receptor)

2007-02-01  

Identity

HGNC
GHSR
LOCATION
3q26.31
LOCUSID
2693
ALIAS
GHDP

Other Information

Locus ID:

NCBI: 2693
MIM: 601898
HGNC: 4267
Ensembl: ENSG00000121853

Variants:

dbSNP: 2693
ClinVar: 2693
TCGA: ENSG00000121853
COSMIC: GHSR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121853ENST00000241256Q92847
ENSG00000121853ENST00000427970Q92847

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448073ethanolChemicalVariantAnnotationassociated18828808

References

Pubmed IDYearTitleCitations
384739682024miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor.0
384739682024miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor.0
368887692023Serotonin, ghrelin, and motilin gene/receptor/transporter polymorphisms in childhood functional constipation.0
368887692023Serotonin, ghrelin, and motilin gene/receptor/transporter polymorphisms in childhood functional constipation.0
350168822022Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review.2
354465152022Association of obesity in T2DM with differential polymorphism of ghrelin, growth hormone secretagogue receptor-1 and telomeres maintenance genes.0
350168822022Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review.2
354465152022Association of obesity in T2DM with differential polymorphism of ghrelin, growth hormone secretagogue receptor-1 and telomeres maintenance genes.0
332644732021Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers.3
337138082021Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity.4
338574722021Unusual orthologs shed new light on the binding mechanism of ghrelin to its receptor GHSR1a.1
339661142021LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish.6
341681172021Allosteric modulation of ghrelin receptor signaling by lipids.17
344174682021Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor.28
346637572021The emerging role of heterodimerisation and interacting proteins in ghrelin receptor function.4

Citation

Dessen P

GHSR (growth hormone secretagogue receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46445