IFNL1 (interferon lambda 1)

2007-02-01  

Identity

HGNC
IFNL1
LOCATION
19q13.2
LOCUSID
282618
ALIAS
IL-29,IL29
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 282618
MIM: 607403
HGNC: 18363
Ensembl: ENSG00000182393

Variants:

dbSNP: 282618
ClinVar: 282618
TCGA: ENSG00000182393
COSMIC: IFNL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182393ENST00000333625Q8IU54

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

References

Pubmed IDYearTitleCitations
382718272024IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study.0
382812342024Up and away with cervical cancer: IL-29 is a promising cytokine for immunotherapy of cervical cancer due to its powerful upregulation of p18, p27, and TRAILR1.0
387008852024Coinfection with respiratory syncytial virus and rhinovirus increases IFN-λ1 and CXCL10 expression in human primary bronchial epithelial cells.0
382718272024IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study.0
382812342024Up and away with cervical cancer: IL-29 is a promising cytokine for immunotherapy of cervical cancer due to its powerful upregulation of p18, p27, and TRAILR1.0
387008852024Coinfection with respiratory syncytial virus and rhinovirus increases IFN-λ1 and CXCL10 expression in human primary bronchial epithelial cells.0
365373342023Interleukin-29 Accelerates Vascular Calcification via JAK2/STAT3/BMP2 Signaling.7
366351582023Enhanced production of interleukin-29 and related genes are associated with T helper 1 cell parameters in patients with type 2 diabetes mellitus.0
365373342023Interleukin-29 Accelerates Vascular Calcification via JAK2/STAT3/BMP2 Signaling.7
366351582023Enhanced production of interleukin-29 and related genes are associated with T helper 1 cell parameters in patients with type 2 diabetes mellitus.0
350818652022Linagliptin ameliorated interleukin-29-induced reduction of extracellular matrix genes through the nuclear factor erythroid 2-related factor 2 (Nrf2)/sry-type high-mobility-group box (SOX)-9 axis in an in vitro study on C-28/I2 chondrocytes.2
357804372022Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells.6
350818652022Linagliptin ameliorated interleukin-29-induced reduction of extracellular matrix genes through the nuclear factor erythroid 2-related factor 2 (Nrf2)/sry-type high-mobility-group box (SOX)-9 axis in an in vitro study on C-28/I2 chondrocytes.2
357804372022Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells.6
325572592021Interleukin-29 and interleukin-28A induce migration of neutrophils in rheumatoid arthritis.3

Citation

Dessen P

IFNL1 (interferon lambda 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46450/js/gene-fusions-explorer/