Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2740
MIM: 138032
HGNC: 4324
Ensembl: ENSG00000112164
Variants:
dbSNP: 2740
ClinVar: 2740
TCGA: ENSG00000112164
COSMIC: GLP1R
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000112164 | ENST00000373256 | P43220 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164748978 | sitagliptin | Chemical | ClinicalAnnotation | associated | PD | 27160388 | |
| PA164749238 | exenatide | Chemical | VariantAnnotation | associated | PD | 30883264 | |
| PA165958346 | vildagliptin | Chemical | ClinicalAnnotation | associated | PD | 27160388 | |
| PA165958364 | liraglutide | Chemical | ClinicalAnnotation | associated | PD | 25991051 | |
| PA443890 | Diabetes Mellitus, Type 2 | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 27160388, 30883264 | |
| PA445131 | Obesity | Disease | ClinicalAnnotation | associated | PD | 25991051 | |
| PA445376 | Polycystic Ovary Syndrome | Disease | ClinicalAnnotation | associated | PD | 25991051 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | 24624910 | ||
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | 24624910 | ||
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | 24624910 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37978261 | 2024 | Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity. | 0 |
| 38444070 | 2024 | A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS. | 0 |
| 38461904 | 2024 | The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation. | 2 |
| 38674415 | 2024 | Association between the GLP1R A316T Mutation and Adolescent Idiopathic Scoliosis in French Canadian and Italian Cohorts. | 0 |
| 38838642 | 2024 | Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule. | 0 |
| 37978261 | 2024 | Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity. | 0 |
| 38444070 | 2024 | A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS. | 0 |
| 38461904 | 2024 | The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation. | 2 |
| 38674415 | 2024 | Association between the GLP1R A316T Mutation and Adolescent Idiopathic Scoliosis in French Canadian and Italian Cohorts. | 0 |
| 38838642 | 2024 | Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule. | 0 |
| 36373695 | 2023 | Glucagon-Like Peptide-1 (GLP-1) Rescue Diabetic Cardiac Dysfuntions in Human iPSC-Derived Cardiomyocytes. | 0 |
| 36592699 | 2023 | Pulsed electric fields stimulate microglial transmitter release of VEGF, IL-8 and GLP-1 and activate endothelial cells through paracrine signaling. | 1 |
| 36675217 | 2023 | GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives. | 26 |
| 36774542 | 2023 | Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells. | 5 |
| 36799940 | 2023 | Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies. | 8 |
Citation
Dessen P
GLP1R (glucagon like peptide 1 receptor)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46453/glp1r
