WSB2 (WD repeat and SOCS box containing 2)

2007-02-01  

Identity

HGNC
WSB2
LOCATION
12q24.23
LOCUSID
55884
ALIAS
SBA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55884
HGNC: 19222
Ensembl: ENSG00000176871

Variants:

dbSNP: 55884
ClinVar: 55884
TCGA: ENSG00000176871
COSMIC: WSB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176871ENST00000315436Q9NYS7
ENSG00000176871ENST00000441406Q9NYS7
ENSG00000176871ENST00000535496F5H280
ENSG00000176871ENST00000537945F5GXB6
ENSG00000176871ENST00000543186F5H2L7
ENSG00000176871ENST00000543218F5H024
ENSG00000176871ENST00000544233Q9NYS7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381772952024Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma.0
384522062024WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.0
381772952024Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma.0
384522062024WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.0
329453702020miR‑28‑5p inhibits the migration of breast cancer by regulating WSB2.11
329453702020miR‑28‑5p inhibits the migration of breast cancer by regulating WSB2.11
311038222019WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells.10
311038222019WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells.10
200599632010Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2.4
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
200599632010Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2.4
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
118198272001Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer.6
118198272001Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer.6

Citation

Dessen P

WSB2 (WD repeat and SOCS box containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46462