CRH (corticotropin releasing hormone)

2007-02-01  

Identity

HGNC
CRH
LOCATION
8q13.1
LOCUSID
1392
ALIAS
CRF,CRH1

Other Information

Locus ID:

NCBI: 1392
MIM: 122560
HGNC: 2355
Ensembl: ENSG00000147571

Variants:

dbSNP: 1392
ClinVar: 1392
TCGA: ENSG00000147571
COSMIC: CRH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147571ENST00000276571P06850
ENSG00000147571ENST00000276571A0A0S2Z478

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Long-term depressionKEGGko04730
Long-term depressionKEGGhsa04730
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
381840942024The peripheral corticotropin releasing factor family's role in vasculitis.0
386168212024Role of CRH in colitis and colitis-associated cancer: a combinative result of central and peripheral effects?0
381840942024The peripheral corticotropin releasing factor family's role in vasculitis.0
386168212024Role of CRH in colitis and colitis-associated cancer: a combinative result of central and peripheral effects?0
359837922023Increases in maternal depressive symptoms during pregnancy and infant cortisol reactivity: Mediation by placental corticotropin-releasing hormone.7
365291262023Expression of Wilms' Tumor 1 Antigen, Vimentin, and Corticotropin-Releasing Factor in the Human Kidney with Focal Segmental Glomerulosclerosis and Effect of Oxidative Stress on These Markers in HEK 293 Cells.1
374013762023Sex-dependent association of DNA methylation in the coding region of the corticotropin-releasing hormone gene and schizophrenia spectrum disorder.0
359837922023Increases in maternal depressive symptoms during pregnancy and infant cortisol reactivity: Mediation by placental corticotropin-releasing hormone.7
365291262023Expression of Wilms' Tumor 1 Antigen, Vimentin, and Corticotropin-Releasing Factor in the Human Kidney with Focal Segmental Glomerulosclerosis and Effect of Oxidative Stress on These Markers in HEK 293 Cells.1
374013762023Sex-dependent association of DNA methylation in the coding region of the corticotropin-releasing hormone gene and schizophrenia spectrum disorder.0
359051072022Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients.0
359389032022An Insertion Variant in CRH Confers an Increased Risk of Central Serous Chorioretinopathy.2
361266172022Different oxytocin and corticotropin-releasing hormone system changes in bipolar disorder and major depressive disorder patients.3
359051072022Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients.0
359389032022An Insertion Variant in CRH Confers an Increased Risk of Central Serous Chorioretinopathy.2

Citation

Dessen P

CRH (corticotropin releasing hormone)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46467