HOXB4 (homeobox B4)

2007-02-01 Affiliation

Identity

HGNC

HOXB4

LOCATION

17q21.32

LOCUSID

3214

ALIAS

HOX-2.6,HOX2,HOX2F

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3214
MIM: 142965
HGNC: 5115
Ensembl: ENSG00000182742

Variants:

dbSNP: 3214
ClinVar: 3214
TCGA: ENSG00000182742
COSMIC: HOXB4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182742	ENST00000332503	P17483

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA30128	KIT	Gene	MultilinkAnnotation	associated			17253940

References

Pubmed ID	Year	Title	Citations
38182548	2024	LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits glycolysis and ovarian cancer progression by destabilizing c-Myc.	1
38182548	2024	LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits glycolysis and ovarian cancer progression by destabilizing c-Myc.	1
36415199	2022	[miRNA-181a-5p inhibits proliferation and migration of osteosarcoma cell line HOS by targeting HOXB4].	0
36415199	2022	[miRNA-181a-5p inhibits proliferation and migration of osteosarcoma cell line HOS by targeting HOXB4].	0
33479226	2021	HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway.	12
33479226	2021	HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway.	12
32178630	2020	HOXB4 promotes the malignant progression of ovarian cancer via DHDDS.	7
32178630	2020	HOXB4 promotes the malignant progression of ovarian cancer via DHDDS.	7
28969513	2018	HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis.	6
29660518	2018	HOXB4 knockdown enhances the cytotoxic effect of paclitaxel and cisplatin by downregulating ABC transporters in ovarian cancer cells.	9
30419846	2018	MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms.	7
28969513	2018	HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis.	6
29660518	2018	HOXB4 knockdown enhances the cytotoxic effect of paclitaxel and cisplatin by downregulating ABC transporters in ovarian cancer cells.	9
30419846	2018	MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms.	7
29039487	2017	Functional analysis of HOXA10 and HOXB4 in human medulloblastoma cell lines.	6

Citation

Dessen P

HOXB4 (homeobox B4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46471