LEP (leptin)

2007-02-01  

Identity

HGNC
LEP
LOCATION
7q32.1
LOCUSID
3952
ALIAS
LEPD,OB,OBS

Other Information

Locus ID:

NCBI: 3952
MIM: 164160
HGNC: 6553
Ensembl: ENSG00000174697

Variants:

dbSNP: 3952
ClinVar: 3952
TCGA: ENSG00000174697
COSMIC: LEP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174697ENST00000308868P41159
ENSG00000174697ENST00000308868A4D0Y8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Neuroactive ligand-receptor interactionKEGGko04080
Jak-STAT signaling pathwayKEGGko04630
Adipocytokine signaling pathwayKEGGko04920
Cytokine-cytokine receptor interactionKEGGhsa04060
Neuroactive ligand-receptor interactionKEGGhsa04080
Jak-STAT signaling pathwayKEGGhsa04630
Adipocytokine signaling pathwayKEGGhsa04920
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Synthesis, secretion, and deacylation of GhrelinREACTOMER-HSA-422085
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Signal TransductionREACTOMER-HSA-162582
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA153906318Autism Spectrum DisorderDiseaseClinicalAnnotationassociatedPD19873684, 21510767, 23799528, 26880915
PA447209Mood DisordersDiseaseClinicalAnnotationassociatedPD19873684, 21510767, 23799528, 26880915
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD18681781
PA450688olanzapineChemicalClinicalAnnotationassociatedPD18681781
PA451257risperidoneChemicalClinicalAnnotationassociatedPD19873684, 21510767, 23799528, 26880915
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD19873684, 21510767, 23799528, 26880915

References

Pubmed IDYearTitleCitations
365835022024Leptin and energy balance: exploring Leptin's role in the regulation of energy intake and energy expenditure.6
377978142024Dynamic Amygdala Nuclei Alterations in Relation to Weight Status in Anorexia Nervosa Are Mediated by Leptin.1
378552242024The role of adiposity, adipokines and polymorphisms of leptin and adiponectin in myelodysplastic syndromes.0
378723792024Twenty-four-hour ambulatory, but not clinic blood pressure associates with leptin in young adults with overweight or obesity: The African-PREDICT study.0
379248102024The solution structure of human leptin reveals a conformational plasticity important for receptor recognition.0
379497102024The role of leptin in ischemic stroke and its subtypes: A Mendelian randomization study.0
380654282024Exploring the folding landscape of leptin: Insights into threading pathways.0
380907452024Leptin secreted by adipocytes promotes EMT transition and endometrial cancer progression via the JAK2/STAT3 signalling pathway.0
380917232024Whether serum leptin and insulin-like growth factor-1 are predictive biomarkers for post-stroke depression: A meta-analysis and systematic review.0
380950622024Leptin and adiposity measures from birth to later childhood: Findings from the Hyperglycemia and Adverse Pregnancy Outcomes Follow-Up Study.0
382067662024Linking adipose tissue eosinophils, IL-4, and leptin in human obesity and insulin resistance.1
382562082024Molecular and Cellular Mechanisms Underlying the Cardiac Hypertrophic and Pro-Remodelling Effects of Leptin.0
382756202024Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth.0
382826112024Leptin promotes proliferation of human undifferentiated spermatogonia by activating the PI3K/AKT/mTOR pathway.0
384905172024Novel mechanisms involved in leptin sensitization in obesity.0

Citation

Dessen P

LEP (leptin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46475