PLEK (pleckstrin)

2007-02-01 Affiliation

Identity

HGNC

PLEK

LOCATION

2p14

LOCUSID

5341

ALIAS

P47

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5341
MIM: 173570
HGNC: 9070
Ensembl: ENSG00000115956

Variants:

dbSNP: 5341
ClinVar: 5341
TCGA: ENSG00000115956
COSMIC: PLEK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115956	ENST00000234313	P08567

Expression (GTEx)

100

150

200

250

300

350

400

450

500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37861500	2023	Higher expression of PLEK and LY86 as the potential biomarker of carotid atherosclerosis.	1
37861500	2023	Higher expression of PLEK and LY86 as the potential biomarker of carotid atherosclerosis.	1
35087525	2021	Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts.	4
35087525	2021	Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts.	4
32337552	2020	A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.	7
32337552	2020	A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.	7
26680696	2015	The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.	6
26686060	2015	Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases.	28
26680696	2015	The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.	6
26686060	2015	Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases.	28
21393855	2011	Crystallization and preliminary diffraction analysis of truncated human pleckstrin.	1
21393855	2011	Crystallization and preliminary diffraction analysis of truncated human pleckstrin.	1
19944685	2010	Novel role of pleckstrin homology domain of the Bcr-Abl protein: analysis of protein-protein and protein-lipid interactions.	4
20190752	2010	Multiple common variants for celiac disease influencing immune gene expression.	471
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15

Citation

Dessen P

PLEK (pleckstrin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46495/haematological-explorer/gene-fusions-explorer/teaching-explorer/