UCHL5 (ubiquitin C-terminal hydrolase L5)

2007-02-01  

Identity

HGNC
UCHL5
LOCATION
1q31.2
LOCUSID
51377
ALIAS
CGI-70,INO80R,UCH-L5,UCH37
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51377
MIM: 610667
HGNC: 19678
Ensembl: ENSG00000116750

Variants:

dbSNP: 51377
ClinVar: 51377
TCGA: ENSG00000116750
COSMIC: UCHL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116750ENST00000367448Q9Y5K5
ENSG00000116750ENST00000367449Q9Y5K5
ENSG00000116750ENST00000367450Q5LJA9
ENSG00000116750ENST00000367451Q5LJA5
ENSG00000116750ENST00000367454Q9Y5K5
ENSG00000116750ENST00000367455Q9Y5K5
ENSG00000116750ENST00000416915H0Y4K0
ENSG00000116750ENST00000417752Q5LJB1
ENSG00000116750ENST00000420791H0Y6Y4
ENSG00000116750ENST00000421683Q5LJB0
ENSG00000116750ENST00000443327H0Y4E0
ENSG00000116750ENST00000449480H0Y636

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387734332024UCHL5 promotes hepatocellular carcinoma progression by promoting glycolysis through activating Wnt/β-catenin pathway.0
387734332024UCHL5 promotes hepatocellular carcinoma progression by promoting glycolysis through activating Wnt/β-catenin pathway.0
377620052023The TGF-β/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta.1
377620052023The TGF-β/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta.1
352566672022UCHL5 controls β-catenin destruction complex function through Axin1 regulation.4
354896842022A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37.2
363281942022Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).9
352566672022UCHL5 controls β-catenin destruction complex function through Axin1 regulation.4
354896842022A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37.2
363281942022Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).9
344317172021Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells.15
366543852021MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.4
344317172021Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells.15
366543852021MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.4
323515842020LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.23

Citation

Dessen P

UCHL5 (ubiquitin C-terminal hydrolase L5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46496