PAOX (polyamine oxidase)

2007-02-01  

Identity

HGNC
PAOX
LOCATION
10q26.3
LOCUSID
196743
ALIAS
PAO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 196743
MIM: 615853
HGNC: 20837
Ensembl: ENSG00000148832

Variants:

dbSNP: 196743
ClinVar: 196743
TCGA: ENSG00000148832
COSMIC: PAOX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148832ENST00000278060Q6QHF9
ENSG00000148832ENST00000356306Q6QHF9
ENSG00000148832ENST00000357296Q6QHF9
ENSG00000148832ENST00000476834Q6QHF9
ENSG00000148832ENST00000480071Q6QHF9
ENSG00000148832ENST00000483211Q6QHF9
ENSG00000148832ENST00000529585Q6QHF9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Interconversion of polyaminesREACTOMER-HSA-351200
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Amine Oxidase reactionsREACTOMER-HSA-140179
PAOs oxidise polyamines to aminesREACTOMER-HSA-141334

References

Pubmed IDYearTitleCitations
358868682022Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells.3
358868682022Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells.3
310167882019Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients.1
310167882019Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients.1
265475062016Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in primary myelofibrosis.6
265475062016Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in primary myelofibrosis.6
204053122010Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus?9
204053122010Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus?9
163546692006Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase.4
163546692006Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase.4
162077102005Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.55
162077102005Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.55

Citation

Dessen P

PAOX (polyamine oxidase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46509