HELZ (helicase with zinc finger)

2007-02-01  

Identity

HGNC
HELZ
LOCATION
17q24.2
LOCUSID
9931
ALIAS
DHRC,DRHC,HUMORF5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9931
MIM: 606699
HGNC: 16878
Ensembl: ENSG00000198265

Variants:

dbSNP: 9931
ClinVar: 9931
TCGA: ENSG00000198265
COSMIC: HELZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198265ENST00000358691P42694
ENSG00000198265ENST00000417253A0A075B6R3
ENSG00000198265ENST00000578783J3QRR8
ENSG00000198265ENST00000579861J3KS59
ENSG00000198265ENST00000579953P42694
ENSG00000198265ENST00000580168J3QS41
ENSG00000198265ENST00000581159J3KT20

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
217659402011The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.11
217659402011The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.11
203786642010Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.6
203786642010Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.6
126918222003Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth.3
126918222003Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth.3

Citation

Dessen P

HELZ (helicase with zinc finger)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46523