Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3122
MIM: 142860
HGNC: 4947
Ensembl: ENSG00000204287
Variants:
dbSNP: 3122
ClinVar: 3122
TCGA: ENSG00000204287
COSMIC: HLA-DRA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000204287 | ENST00000374982 | Q30118 |
| ENSG00000204287 | ENST00000395388 | P01903 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164742987 | clavulanate | Chemical | VariantAnnotation | associated | PD | 30664875 | |
| PA164781042 | flucloxacillin | Chemical | VariantAnnotation | associated | PD | 30664875 | |
| PA166119041 | drug-induced liver injury | Disease | VariantAnnotation | associated | PD | 30664875 | |
| PA448406 | amoxicillin | Chemical | VariantAnnotation | associated | PD | 30664875 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38942763 | 2024 | Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease. | 0 |
| 38942763 | 2024 | Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease. | 0 |
| 35543859 | 2022 | Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer. | 8 |
| 35794593 | 2022 | HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC. | 9 |
| 35895219 | 2022 | Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis development in the Korean population. | 2 |
| 35543859 | 2022 | Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer. | 8 |
| 35794593 | 2022 | HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC. | 9 |
| 35895219 | 2022 | Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis development in the Korean population. | 2 |
| 32253955 | 2021 | The rs3129882/rs4248166 in HLA-DRA and rs34372695 in SYT11 are not associated with sporadic Parkinson's disease in Central Chinese population. | 0 |
| 34311991 | 2021 | Tri-SNP polymorphism in the intron of HLA-DRA1 affects type 1 diabetes susceptibility in the Finnish population. | 3 |
| 34402606 | 2021 | Identification of three novel HLA-DRA alleles by next-generation sequencing. | 0 |
| 34858413 | 2021 | Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection. | 3 |
| 32253955 | 2021 | The rs3129882/rs4248166 in HLA-DRA and rs34372695 in SYT11 are not associated with sporadic Parkinson's disease in Central Chinese population. | 0 |
| 34311991 | 2021 | Tri-SNP polymorphism in the intron of HLA-DRA1 affects type 1 diabetes susceptibility in the Finnish population. | 3 |
| 34402606 | 2021 | Identification of three novel HLA-DRA alleles by next-generation sequencing. | 0 |
Citation
Dessen P
HLA-DRA (major histocompatibility complex, class II, DR alpha)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46550/hla-dra
