SAA1 (serum amyloid A1)

2007-02-01  

Identity

HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
PIG4,SAA,SAA2,TP53I4
FUSION GENES

Other Information

Locus ID:

NCBI: 6288
MIM: 104750
HGNC: 10513
Ensembl: ENSG00000173432

Variants:

dbSNP: 6288
ClinVar: 6288
TCGA: ENSG00000173432
COSMIC: SAA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173432ENST00000356524P0DJI8
ENSG00000173432ENST00000405158P0DJI8
ENSG00000173432ENST00000532858E9PQD6
ENSG00000173432ENST00000649195A0A3B3ISW8

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000
9000

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
TAK1 activates NFkB by phosphorylation and activation of IKKs complexREACTOMER-HSA-445989
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Advanced glycosylation endproduct receptor signalingREACTOMER-HSA-879415
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF6 mediated NF-kB activationREACTOMER-HSA-933542
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNsREACTOMER-HSA-1606322
RIP-mediated NFkB activation via ZBP1REACTOMER-HSA-1810476
DEx/H-box helicases activate type I IFN and inflammatory cytokines productionREACTOMER-HSA-3134963
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Formyl peptide receptors bind formyl peptides and many other ligandsREACTOMER-HSA-444473
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class B ReceptorsREACTOMER-HSA-3000471
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
382143322024Serum amyloid A facilitates expansion of CD4(+) T cell and CD19(+) B cell subsets implicated in the severity of myasthenia gravis patients.0
382890162024SAA1-dependent reprogramming of adipocytes by tumor cells is associated with triple negative breast cancer aggressiveness.1
382143322024Serum amyloid A facilitates expansion of CD4(+) T cell and CD19(+) B cell subsets implicated in the severity of myasthenia gravis patients.0
382890162024SAA1-dependent reprogramming of adipocytes by tumor cells is associated with triple negative breast cancer aggressiveness.1
363456582023Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.4
368790642023Amnion-derived serum amyloid A1 participates in sterile inflammation of fetal membranes at parturition.0
371086662023SAA1 Has Potential as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, and an Indicator for Immune Infiltration of Tumor Microenvironment in Clear Cell Renal Cell Carcinoma.2
374221102023The diagnostic and prognostic value of SAA1 as a novel biomarker for acute aortic dissection.1
382034822023IL-6 and SAA-Strong Predictors for the Outcome in COVID-19 CKD Patients.0
363456582023Serum amyloid A1 recruits neutrophils to the invasive front of T1 colorectal cancers.4
368790642023Amnion-derived serum amyloid A1 participates in sterile inflammation of fetal membranes at parturition.0
371086662023SAA1 Has Potential as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, and an Indicator for Immune Infiltration of Tumor Microenvironment in Clear Cell Renal Cell Carcinoma.2
374221102023The diagnostic and prognostic value of SAA1 as a novel biomarker for acute aortic dissection.1
382034822023IL-6 and SAA-Strong Predictors for the Outcome in COVID-19 CKD Patients.0
345601382022A mutation in the SAA1 promoter causes hereditary amyloid A amyloidosis.5

Citation

Dessen P

SAA1 (serum amyloid A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46569/saa1