Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3038
MIM: 602428
HGNC: 4820
Ensembl: ENSG00000103044
Variants:
dbSNP: 3038
ClinVar: 3038
TCGA: ENSG00000103044
COSMIC: HAS3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000103044 | ENST00000219322 | O00219 |
| ENSG00000103044 | ENST00000306560 | O00219 |
| ENSG00000103044 | ENST00000566118 | H3BRH5 |
| ENSG00000103044 | ENST00000569188 | O00219 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA130620651 | anthracyclines and related substances | Chemical | ClinicalAnnotation | associated | PD | ||
| PA445018 | Cardiomyopathies | Disease | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38402581 | 2024 | Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis. | 1 |
| 38844132 | 2024 | Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3. | 0 |
| 38402581 | 2024 | Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis. | 1 |
| 38844132 | 2024 | Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3. | 0 |
| 35269567 | 2022 | A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. | 1 |
| 35998871 | 2022 | Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response. | 2 |
| 36497040 | 2022 | 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression. | 0 |
| 35269567 | 2022 | A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. | 1 |
| 35998871 | 2022 | Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response. | 2 |
| 36497040 | 2022 | 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression. | 0 |
| 34380333 | 2021 | Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling. | 2 |
| 34380333 | 2021 | Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling. | 2 |
| 31820036 | 2020 | HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells. | 16 |
| 31948751 | 2020 | The regulation of HAS3 by miR-10b and miR-29a in neuroendocrine transdifferentiated LNCaP prostate cancer cells. | 7 |
| 31820036 | 2020 | HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells. | 16 |
Citation
Dessen P
HAS3 (hyaluronan synthase 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46583/has3
