Identity
HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
GRIM-12,TR,TR1,TRXR1,TXNR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7296
MIM: 601112
HGNC: 12437
Ensembl: ENSG00000198431
Variants:
dbSNP: 7296
ClinVar: 7296
TCGA: ENSG00000198431
COSMIC: TXNRD1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA37091 | TXN | Gene | Pathway | associated | 23913015 | ||
| PA451898 | vitamin c | Chemical | Pathway | associated | 23913015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38153696 | 2024 | LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1. | 0 |
| 38243044 | 2024 | PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway. | 0 |
| 38277963 | 2024 | Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. | 0 |
| 38565059 | 2024 | Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells. | 0 |
| 38636790 | 2024 | Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer. | 0 |
| 38153696 | 2024 | LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1. | 0 |
| 38243044 | 2024 | PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway. | 0 |
| 38277963 | 2024 | Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. | 0 |
| 38565059 | 2024 | Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells. | 0 |
| 38636790 | 2024 | Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer. | 0 |
| 35066751 | 2023 | Selenite Ameliorates Cadmium-induced Cytotoxicity Through Downregulation of ROS Levels and Upregulation of Selenoprotein Thioredoxin Reductase 1 in SH-SY5Y Cells. | 7 |
| 36560881 | 2023 | Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma. | 4 |
| 36577250 | 2023 | Inhibition of thioredoxin reductase activity reduces the antioxidant defense capacity of human pluripotent stem cells under conditions of mild but not severe oxidative stress. | 2 |
| 36633484 | 2023 | Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury. | 3 |
| 36754152 | 2023 | TXNRD1 knockdown inhibits the proliferation of endothelial cells subjected to oscillatory shear stress via activation of the endothelial nitric oxide synthase/apoptosis pathway. | 1 |
Citation
Dessen P
TXNRD1 (thioredoxin reductase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46587/txnrd1
