HMGN1 (high mobility group nucleosome binding domain 1)

2007-02-01  

Identity

HGNC
HMGN1
LOCATION
21q22.2
LOCUSID
3150
ALIAS
HMG14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3150
MIM: 163920
HGNC: 4984
Ensembl: ENSG00000205581

Variants:

dbSNP: 3150
ClinVar: 3150
TCGA: ENSG00000205581
COSMIC: HMGN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205581ENST00000288344H7BXJ5
ENSG00000205581ENST00000380747A6NEL0
ENSG00000205581ENST00000380748A6NL93
ENSG00000205581ENST00000380749P05114
ENSG00000205581ENST00000419378F2Z2Y5
ENSG00000205581ENST00000431390F2Z2Y5
ENSG00000205581ENST00000436324F2Z2W6
ENSG00000205581ENST00000443046F2Z2W6
ENSG00000205581ENST00000652622A0A494C035

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
348578872022HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort.10
364632992022Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain.0
348578872022HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort.10
364632992022Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain.0
349469492021Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.1
349469492021Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.1
295031232018High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin.15
304283562018Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression.32
295031232018High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin.15
304283562018Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression.32
289734352017HMGN1 and 2 remodel core and linker histone tail domains within chromatin.32
289734352017HMGN1 and 2 remodel core and linker histone tail domains within chromatin.32
271000872016Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.12
271000872016Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.12
261134102015High-mobility group nucleosome-binding protein 1 is a novel clinical biomarker in non-small cell lung cancer.11

Citation

Dessen P

HMGN1 (high mobility group nucleosome binding domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46588