GCLC (glutamate-cysteine ligase catalytic subunit)

2007-02-01  

Identity

HGNC
GCLC
LOCATION
6p12.1
LOCUSID
2729
ALIAS
GCL,GCS,GLCL,GLCLC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2729
MIM: 606857
HGNC: 4311
Ensembl: ENSG00000001084

Variants:

dbSNP: 2729
ClinVar: 2729
TCGA: ENSG00000001084
COSMIC: GCLC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000001084ENST00000504525D6RGF8
ENSG00000001084ENST00000505197D6RIT4
ENSG00000001084ENST00000509541A0A2R8Y648
ENSG00000001084ENST00000513939E1CEI4
ENSG00000001084ENST00000514004A0A0C4DGB2
ENSG00000001084ENST00000616923B4E2I4
ENSG00000001084ENST00000643939A0A2R8YEL6
ENSG00000001084ENST00000650454P48506
ENSG00000001084ENST00000650454Q14TF0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Glutathione biosynthesis, glutamate => glutathioneKEGGhsa_M00118
Glutathione biosynthesis, glutamate => glutathioneKEGGM00118
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447230HIVDiseaseClinicalAnnotationassociatedPD22824134
PA451544sulfamethoxazoleChemicalClinicalAnnotationassociatedPD22824134

References

Pubmed IDYearTitleCitations
352413412023Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma.3
371466982023H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells.6
380498652023SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation.1
352413412023Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma.3
371466982023H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells.6
380498652023SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation.1
346429122022Association of Polymorphisms of Glutamate Cysteine Ligase Genes GCLC C-129 T and GCLM C-588 T with Risk of Polycystic Ovary Syndrome in Chinese Women.3
353860702022Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study.3
363597682022Ferroptosis-Related Gene GCLC Is a Novel Prognostic Molecular and Correlates with Immune Infiltrates in Lung Adenocarcinoma.5
346429122022Association of Polymorphisms of Glutamate Cysteine Ligase Genes GCLC C-129 T and GCLM C-588 T with Risk of Polycystic Ovary Syndrome in Chinese Women.3
353860702022Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study.3
363597682022Ferroptosis-Related Gene GCLC Is a Novel Prognostic Molecular and Correlates with Immune Infiltrates in Lung Adenocarcinoma.5
333574552021Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis.117
333574552021Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis.117
320543662020Genetic susceptibility analysis of GCLC rs17883901 polymorphism to preeclampsia in Chinese Han women.1

Citation

Dessen P

GCLC (glutamate-cysteine ligase catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46590