EIF4A1 (eukaryotic translation initiation factor 4A1)

2007-04-01  

Identity

HGNC
EIF4A1
LOCATION
17p13.1
LOCUSID
1973
ALIAS
DDX2A,EIF-4A,EIF4A,eIF-4A-I,eIF4A-I
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1973
MIM: 602641
HGNC: 3282
Ensembl: ENSG00000161960

Variants:

dbSNP: 1973
ClinVar: 1973
TCGA: ENSG00000161960
COSMIC: EIF4A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161960ENST00000293831P60842
ENSG00000161960ENST00000577269P60842
ENSG00000161960ENST00000577929J3KS93
ENSG00000161960ENST00000578476J3QRP5
ENSG00000161960ENST00000578495J3QS69
ENSG00000161960ENST00000578754J3KTN0
ENSG00000161960ENST00000579139J3KRC2
ENSG00000161960ENST00000580461J3QRP5
ENSG00000161960ENST00000580888J3KSP3
ENSG00000161960ENST00000581384J3QR64
ENSG00000161960ENST00000581544J3QQP0
ENSG00000161960ENST00000581770J3KT04
ENSG00000161960ENST00000582050J3QL52
ENSG00000161960ENST00000582169J3QKZ9
ENSG00000161960ENST00000582746J3KT12
ENSG00000161960ENST00000583389J3KSZ0
ENSG00000161960ENST00000583802J3QLN6
ENSG00000161960ENST00000584784J3QL43
ENSG00000161960ENST00000584860J3KTB5
ENSG00000161960ENST00000585024J3KS25

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
eIF4F complexKEGGhsa_M00428
eIF4F complexKEGGM00428
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387388572024mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3(IBTK)-mediated ubiquitination of eIF4A1 in cancer cells.0
387388572024mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3(IBTK)-mediated ubiquitination of eIF4A1 in cancer cells.0
367274612023eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.5
367683802023eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma.1
367274612023eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.5
367683802023eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma.1
353618832022Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.7
365528342022eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model.5
353618832022Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.7
365528342022eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model.5
336328982021Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.17
336328982021Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.17
320149992020A comparative study of small molecules targeting eIF4A.17
321476842020High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.24
323922432020ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection.4

Citation

Dessen P

EIF4A1 (eukaryotic translation initiation factor 4A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46639