DHX36 (DEAH-box helicase 36)

2007-04-01  

Identity

HGNC
DHX36
LOCATION
3q25.2
LOCUSID
170506
ALIAS
DDX36,G4R1,MLEL1,RHAU
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 170506
MIM: 612767
HGNC: 14410
Ensembl: ENSG00000174953

Variants:

dbSNP: 170506
ClinVar: 170506
TCGA: ENSG00000174953
COSMIC: DHX36

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174953ENST00000308361Q9H2U1
ENSG00000174953ENST00000329463Q9H2U1
ENSG00000174953ENST00000469977H7C5F5
ENSG00000174953ENST00000479934H7C514
ENSG00000174953ENST00000481941E7EWK3
ENSG00000174953ENST00000496811Q9H2U1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingREACTOMER-HSA-975110
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
DEx/H-box helicases activate type I IFN and inflammatory cytokines productionREACTOMER-HSA-3134963

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383390292024Differential Gene Expression following DHX36/G4R1 Knockout Is Associated with G-Quadruplex Content and Cancer.1
383390292024Differential Gene Expression following DHX36/G4R1 Knockout Is Associated with G-Quadruplex Content and Cancer.1
330219602021The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes.9
338573592021The DHX36-specific-motif (DSM) enhances specificity by accelerating recruitment of DNA G-quadruplex structures.4
341742882021The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation.21
347838012021G4-PROTAC: targeted degradation of a G-quadruplex binding protein.15
348628802021G-Quadruplexes and the DNA/RNA helicase DHX36 in health, disease, and aging.11
330219602021The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes.9
338573592021The DHX36-specific-motif (DSM) enhances specificity by accelerating recruitment of DNA G-quadruplex structures.4
341742882021The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation.21
347838012021G4-PROTAC: targeted degradation of a G-quadruplex binding protein.15
348628802021G-Quadruplexes and the DNA/RNA helicase DHX36 in health, disease, and aging.11
315865992020Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex.7
327745612020DHX36, BAX, and ARPC1B May Be Critical for the Diagnosis and Treatment of Tuberculosis.2
315865992020Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex.7

Citation

Dessen P

DHX36 (DEAH-box helicase 36)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46686/css/lib/css/lib/js/web-card-_common.js