PPM1H (protein phosphatase, Mg2+/Mn2+ dependent 1H)

2007-04-01  

Identity

HGNC
PPM1H
LOCATION
12q14.1
LOCUSID
57460
ALIAS
ARHCL1,NERPP-2C,URCC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57460
MIM: 616016
HGNC: 18583
Ensembl: ENSG00000111110

Variants:

dbSNP: 57460
ClinVar: 57460
TCGA: ENSG00000111110
COSMIC: PPM1H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111110ENST00000228705Q9ULR3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371339942023Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.8
378899312023Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.5
371339942023Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.8
378899312023Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.5
338471312021PPM1H is an independent prognostic biomarker of non-small cell lung cancer.0
338471312021PPM1H is an independent prognostic biomarker of non-small cell lung cancer.0
309883942019Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts.6
316638532019PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.67
309883942019Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts.6
316638532019PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.67
275996702016Effect of PPM1H on malignant phenotype of human pancreatic cancer cells.8
275996702016Effect of PPM1H on malignant phenotype of human pancreatic cancer cells.8
247320092014Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.14
247320092014Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.14
225866112011PPM1H is a p27 phosphatase implicated in trastuzumab resistance.22

Citation

Dessen P

PPM1H (protein phosphatase, Mg2+/Mn2+ dependent 1H)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46687