PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)

2003-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
DOD,UBL5
FUSION GENES

Other Information

Locus ID:

NCBI: 5300
MIM: 601052
HGNC: 8988
Ensembl: ENSG00000127445

Variants:

dbSNP: 5300
ClinVar: 5300
TCGA: ENSG00000127445
COSMIC: PIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127445ENST00000247970Q13526
ENSG00000127445ENST00000586352K7EP26
ENSG00000127445ENST00000587625K7EMU7
ENSG00000127445ENST00000588695Q13526
ENSG00000127445ENST00000591777K7EN45

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
PI5P Regulates TP53 AcetylationREACTOMER-HSA-6811555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD
PA166123026progression-free survivalDiseaseVariantAnnotationassociatedPD
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA450085irinotecanChemicalClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
379296602024PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1.2
380848392024Prolyl isomerase Pin1 promotes autophagy and cancer cell viability through activating FoxO3 signalling.1
381472032024The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m(6)A-dependent stabilization of AURKA mRNA.0
381672922024Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.0
382161242024Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence.0
386191042024Stereospecific NANOG PEST Stabilization by Pin1.0
379296602024PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1.2
380848392024Prolyl isomerase Pin1 promotes autophagy and cancer cell viability through activating FoxO3 signalling.1
381472032024The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m(6)A-dependent stabilization of AURKA mRNA.0
381672922024Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.0
382161242024Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence.0
386191042024Stereospecific NANOG PEST Stabilization by Pin1.0
361627032023Pin1 and Alzheimer's disease.4
367550572023METTL3 stabilization by PIN1 promotes breast tumorigenesis via enhanced m(6)A-dependent translation.5
367667692023Spastin Promotes the Migration and Invasion Capability of T98G Glioblastoma Cells by Interacting with Pin1 through Its Microtubule-Binding Domain.0

Citation

Dessen P

PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/467/js/favicon/teaching-explorer/