DDX4 (DEAD-box helicase 4)

2007-04-01 Affiliation

Identity

HGNC

DDX4

LOCATION

5q11.2

LOCUSID

54514

ALIAS

VASA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54514
MIM: 605281
HGNC: 18700
Ensembl: ENSG00000152670

Variants:

dbSNP: 54514
ClinVar: 54514
TCGA: ENSG00000152670
COSMIC: DDX4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000152670	ENST00000353507	Q9NQI0
ENSG00000152670	ENST00000354991	Q9NQI0
ENSG00000152670	ENST00000503129	H0Y960
ENSG00000152670	ENST00000505374	Q9NQI0
ENSG00000152670	ENST00000506511	D6RCM4
ENSG00000152670	ENST00000506848	D6RAF5
ENSG00000152670	ENST00000507645	H0YBW0
ENSG00000152670	ENST00000511491	D6RIB2
ENSG00000152670	ENST00000511853	Q9NQI0
ENSG00000152670	ENST00000514278	Q9NQI0
ENSG00000152670	ENST00000514679	D6RBL3
ENSG00000152670	ENST00000515709	D6RAT7

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Gene Silencing by RNA	REACTOME	R-HSA-211000
PIWI-interacting RNA (piRNA) biogenesis	REACTOME	R-HSA-5601884

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36347925	2023	Discriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue.	0
36653474	2023	The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells.	3
36347925	2023	Discriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue.	0
36653474	2023	The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells.	3
36241908	2022	VASA protein and gene expression analysis of human non-obstructive azoospermia and normal by immunohistochemistry, immunocytochemistry, and bioinformatics analysis.	5
36241908	2022	VASA protein and gene expression analysis of human non-obstructive azoospermia and normal by immunohistochemistry, immunocytochemistry, and bioinformatics analysis.	5
32847044	2020	DEAD-Box Helicase 4 (Ddx4)(+) Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers.	2
32847044	2020	DEAD-Box Helicase 4 (Ddx4)(+) Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers.	2
31212843	2019	Extracellular Localisation of the C-Terminus of DDX4 Confirmed by Immunocytochemistry and Fluorescence-Activated Cell Sorting.	8
31212843	2019	Extracellular Localisation of the C-Terminus of DDX4 Confirmed by Immunocytochemistry and Fluorescence-Activated Cell Sorting.	8
29725036	2018	Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity.	35
29725036	2018	Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity.	35
28000927	2017	Does detection of DDX4 mRNA in cell-free seminal plasma represents a reliable noninvasive germ cell marker in patients with nonobstructive azoospermia?	2
28342926	2017	Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis.	6
28612512	2017	Germline factor DDX4 functions in blood-derived cancer cell phenotypes.	15

Citation

Dessen P

DDX4 (DEAD-box helicase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46735/deep-insight-explorer/gene-fusions/css/lib/dataTables.bootstrap.min.css