Identity
HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
ALDR1,ALR,ARM,DD3,HEL-S-6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10327
MIM: 103830
HGNC: 380
Ensembl: ENSG00000117448
Variants:
dbSNP: 10327
ClinVar: 10327
TCGA: ENSG00000117448
COSMIC: AKR1A1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA449412 | doxorubicin | Chemical | Pathway | associated | 21048526 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38092142 | 2024 | Mechanistic study of the Aldo-keto reductase family 1 member A1 in regulating mesenchymal stem cell fate decision toward adipogenesis and osteogenesis. | 0 |
| 38092142 | 2024 | Mechanistic study of the Aldo-keto reductase family 1 member A1 in regulating mesenchymal stem cell fate decision toward adipogenesis and osteogenesis. | 0 |
| 33158254 | 2020 | (5-Hydroxy-4-oxo-2-styryl-4H-pyridin-1-yl)-acetic Acid Derivatives as Multifunctional Aldose Reductase Inhibitors. | 1 |
| 33158254 | 2020 | (5-Hydroxy-4-oxo-2-styryl-4H-pyridin-1-yl)-acetic Acid Derivatives as Multifunctional Aldose Reductase Inhibitors. | 1 |
| 29763686 | 2018 | Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury. | 3 |
| 29763686 | 2018 | Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury. | 3 |
| 23643085 | 2013 | [Effect of AKR1A1 knock-down on H2;O2; and 4-hydroxynonenal-induced cytotoxicity in human 1321N1 astrocytoma cells]. | 1 |
| 23747692 | 2013 | Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases. | 4 |
| 23643085 | 2013 | [Effect of AKR1A1 knock-down on H2;O2; and 4-hydroxynonenal-induced cytotoxicity in human 1321N1 astrocytoma cells]. | 1 |
| 23747692 | 2013 | Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases. | 4 |
| 21276435 | 2011 | The role of aldehyde reductase AKR1A1 in the metabolism of γ-hydroxybutyrate in 1321N1 human astrocytoma cells. | 3 |
| 21276435 | 2011 | The role of aldehyde reductase AKR1A1 in the metabolism of γ-hydroxybutyrate in 1321N1 human astrocytoma cells. | 3 |
| 19692168 | 2010 | Genetic susceptibility to distinct bladder cancer subphenotypes. | 30 |
| 20453000 | 2010 | A Large-scale genetic association study of esophageal adenocarcinoma risk. | 26 |
| 19692168 | 2010 | Genetic susceptibility to distinct bladder cancer subphenotypes. | 30 |
Citation
Dessen P
AKR1A1 (aldo-keto reductase family 1 member A1)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46740/akr1a1
