Identity
HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
DAP10,KAP10,PIK3AP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10870
MIM: 604089
HGNC: 16977
Ensembl: ENSG00000126264
Variants:
dbSNP: 10870
ClinVar: 10870
TCGA: ENSG00000126264
COSMIC: HCST
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000126264 | ENST00000246551 | Q9UBK5 |
| ENSG00000126264 | ENST00000437550 | Q9UBK5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33153411 | 2020 | CSF1R and HCST: Novel Candidate Biomarkers Predicting the Response to Immunotherapy in Non-Small Cell Lung Cancer. | 10 |
| 33153411 | 2020 | CSF1R and HCST: Novel Candidate Biomarkers Predicting the Response to Immunotherapy in Non-Small Cell Lung Cancer. | 10 |
| 31235500 | 2019 | NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity. | 17 |
| 31235500 | 2019 | NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity. | 17 |
| 26508790 | 2015 | Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells. | 30 |
| 26508790 | 2015 | Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells. | 30 |
| 25002577 | 2014 | DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes. | 11 |
| 25002577 | 2014 | DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes. | 11 |
| 22438812 | 2012 | TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. | 100 |
| 22438812 | 2012 | TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. | 100 |
| 21263069 | 2011 | Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible. | 13 |
| 21706044 | 2011 | HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway. | 19 |
| 21789015 | 2011 | A possible mechanism of impaired NK cytotoxicity in cancer patients: down-regulation of DAP10 by TGF-beta1. | 7 |
| 21816829 | 2011 | Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1. | 52 |
| 21263069 | 2011 | Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible. | 13 |
Citation
Dessen P
HCST (hematopoietic cell signal transducer)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46745/hcst
