Identity
HGNC
LOCATION
14q13.1
LOCUSID
ALIAS
HIFP4H3,HIFPH3,PHD3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 112399
MIM: 606426
HGNC: 14661
Ensembl: ENSG00000129521
Variants:
dbSNP: 112399
ClinVar: 112399
TCGA: ENSG00000129521
COSMIC: EGLN3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000129521 | ENST00000250457 | Q9H6Z9 |
| ENSG00000129521 | ENST00000487915 | G3V3M1 |
| ENSG00000129521 | ENST00000547327 | F8VR39 |
| ENSG00000129521 | ENST00000553215 | F8W1G2 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38184692 | 2024 | EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity. | 0 |
| 38400673 | 2024 | Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma. | 1 |
| 38184692 | 2024 | EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity. | 0 |
| 38400673 | 2024 | Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma. | 1 |
| 36882523 | 2023 | E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression. | 1 |
| 36882523 | 2023 | E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression. | 1 |
| 35088661 | 2022 | PHD3 as a Prognosis Marker and its Relationship with Immune Infiltration in Lung Adenocarcinoma. | 1 |
| 35124697 | 2022 | Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth. | 18 |
| 35088661 | 2022 | PHD3 as a Prognosis Marker and its Relationship with Immune Infiltration in Lung Adenocarcinoma. | 1 |
| 35124697 | 2022 | Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth. | 18 |
| 33571527 | 2021 | Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins. | 4 |
| 33799686 | 2021 | Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo. | 3 |
| 34112167 | 2021 | USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3. | 7 |
| 33571527 | 2021 | Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins. | 4 |
| 33799686 | 2021 | Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo. | 3 |
Citation
Dessen P
EGLN3 (egl-9 family hypoxia inducible factor 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46747/egln3
