Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29947
MIM: 606588
HGNC: 2980
Ensembl: ENSG00000142182
Variants:
dbSNP: 29947
ClinVar: 29947
TCGA: ENSG00000142182
COSMIC: DNMT3L
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000142182 | ENST00000270172 | Q9UJW3 |
| ENSG00000142182 | ENST00000431166 | C9J0T5 |
| ENSG00000142182 | ENST00000628202 | Q9UJW3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Epigenetic regulation of gene expression | REACTOME | R-HSA-212165 |
| DNA methylation | REACTOME | R-HSA-5334118 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38308276 | 2024 | DNMT3L inhibits hepatocellular carcinoma progression through DNA methylation of CDO1: insights from big data to basic research. | 0 |
| 38308276 | 2024 | DNMT3L inhibits hepatocellular carcinoma progression through DNA methylation of CDO1: insights from big data to basic research. | 0 |
| 33750431 | 2021 | Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature. | 9 |
| 33750431 | 2021 | Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature. | 9 |
| 33369458 | 2020 | Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. | 5 |
| 33369458 | 2020 | Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. | 5 |
| 30877840 | 2019 | Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline. | 4 |
| 31515938 | 2019 | EGR1 interacts with DNMT3L to inhibit the transcription of miR-195 and plays an anti-apoptotic role in the development of gastric cancer. | 24 |
| 30877840 | 2019 | Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline. | 4 |
| 31515938 | 2019 | EGR1 interacts with DNMT3L to inhibit the transcription of miR-195 and plays an anti-apoptotic role in the development of gastric cancer. | 24 |
| 26647998 | 2016 | Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility. | 0 |
| 26911678 | 2016 | Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression. | 26 |
| 26647998 | 2016 | Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility. | 0 |
| 26911678 | 2016 | Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression. | 26 |
| 25383530 | 2015 | Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. | 160 |
Citation
Dessen P
DNMT3L (DNA methyltransferase 3 like)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46801/dnmt3l
