PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)

2007-04-01  

Identity

HGNC
PPM1L
LOCATION
3q25.33
LOCUSID
151742
ALIAS
PP2C-epsilon,PP2CE,PPM1-LIKE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 151742
MIM: 611931
HGNC: 16381
Ensembl: ENSG00000163590

Variants:

dbSNP: 151742
ClinVar: 151742
TCGA: ENSG00000163590
COSMIC: PPM1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163590ENST00000295839Q5SGD2
ENSG00000163590ENST00000464260Q5SGD2
ENSG00000163590ENST00000497343Q5SGD2
ENSG00000163590ENST00000498165Q5SGD2

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
227961122012Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites.17
227961122012Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites.17
198478902010Genome-wide scan identifies a copy number variable region at 3q26 that regulates PPM1L in APC mutation-negative familial colorectal cancer patients.20
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
198478902010Genome-wide scan identifies a copy number variable region at 3q26 that regulates PPM1L in APC mutation-negative familial colorectal cancer patients.20
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
181652322008Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.38
181652322008Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.38
174560472007Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.20
174560472007Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.20
155603752004Molecular cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon*).1
155603752004Molecular cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon*).1

Citation

Dessen P

PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46827