Identity
HGNC
LOCATION
10q24.2
LOCUSID
ALIAS
PI4KII,PIK42A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55361
MIM: 609763
HGNC: 30031
Ensembl: ENSG00000155252
Variants:
dbSNP: 55361
ClinVar: 55361
TCGA: ENSG00000155252
COSMIC: PI4K2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000155252 | ENST00000370631 | Q9BTU6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35634680 | 2023 | High expression of PI4K2A predicted poor prognosis of colon adenocarcinoma (COAD) and correlated with immunity. | 4 |
| 35634680 | 2023 | High expression of PI4K2A predicted poor prognosis of colon adenocarcinoma (COAD) and correlated with immunity. | 4 |
| 35880319 | 2022 | PI4K2A deficiency causes innate error in intracellular trafficking with developmental and epileptic-dyskinetic encephalopathy. | 9 |
| 35880319 | 2022 | PI4K2A deficiency causes innate error in intracellular trafficking with developmental and epileptic-dyskinetic encephalopathy. | 9 |
| 31554935 | 2020 | Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. | 13 |
| 31554935 | 2020 | Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. | 13 |
| 30659093 | 2019 | A complex between phosphatidylinositol 4-kinase IIα and integrin α3β1 is required for N-glycan sialylation in cancer cells. | 9 |
| 30659093 | 2019 | A complex between phosphatidylinositol 4-kinase IIα and integrin α3β1 is required for N-glycan sialylation in cancer cells. | 9 |
| 29792687 | 2018 | Comobility of GABARAP and Phosphatidylinositol 4-Kinase 2A on Cytoplasmic Vesicles. | 4 |
| 29792687 | 2018 | Comobility of GABARAP and Phosphatidylinositol 4-Kinase 2A on Cytoplasmic Vesicles. | 4 |
| 28827373 | 2017 | PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. | 17 |
| 28827373 | 2017 | PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. | 17 |
| 26823017 | 2016 | PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes. | 24 |
| 27068535 | 2016 | Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells. | 9 |
| 27798239 | 2016 | Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype. | 7 |
Citation
Dessen P
PI4K2A (phosphatidylinositol 4-kinase type 2 alpha)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46830/pi4k2a
