MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1)

2007-04-01  

Identity

HGNC
MAGI1
LOCATION
3p14.1
LOCUSID
9223
ALIAS
AIP-3,AIP3,BAIAP1,BAP-1,BAP1,MAGI-1,MAGI-1b,Magi1d,TNRC19,WWP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9223
MIM: 602625
HGNC: 946
Ensembl: ENSG00000151276

Variants:

dbSNP: 9223
ClinVar: 9223
TCGA: ENSG00000151276
COSMIC: MAGI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151276ENST00000330909Q96QZ7
ENSG00000151276ENST00000402939Q96QZ7
ENSG00000151276ENST00000460329H7C535
ENSG00000151276ENST00000463103H7C4U7
ENSG00000151276ENST00000472257H7C5T8
ENSG00000151276ENST00000479287H7C4S7
ENSG00000151276ENST00000483466Q96QZ7
ENSG00000151276ENST00000497477Q96QZ7
ENSG00000151276ENST00000611645A0A087WXD2
ENSG00000151276ENST00000621418A0A087WT53

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383253492024MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.0
383253492024MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.0
375660082023MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER(+) Breast Cancer.0
375660082023MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER(+) Breast Cancer.0
351156182022Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain.8
357639132022Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis.5
351156182022Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain.8
357639132022Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis.5
321417932021Genome-Wide Association Study of Ocular Sarcoidosis Confirms HLA Associations and Implicates Barrier Function and Autoimmunity in African Americans.17
337075762021MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis.6
341985842021MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions.11
321417932021Genome-Wide Association Study of Ocular Sarcoidosis Confirms HLA Associations and Implicates Barrier Function and Autoimmunity in African Americans.17
337075762021MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis.6
341985842021MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions.11
310356332019MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress.22

Citation

Dessen P

MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46855