RNF138 (ring finger protein 138)

2007-04-01  

Identity

HGNC
RNF138
LOCATION
18q12.1
LOCUSID
51444
ALIAS
HSD-4,NARF,STRIN,hNARF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51444
MIM: 616319
HGNC: 17765
Ensembl: ENSG00000134758

Variants:

dbSNP: 51444
ClinVar: 51444
TCGA: ENSG00000134758
COSMIC: RNF138

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134758ENST00000257190Q8WVD3
ENSG00000134758ENST00000261593Q8WVD3
ENSG00000134758ENST00000261593A0A140VJT9
ENSG00000134758ENST00000577999J3QLQ3
ENSG00000134758ENST00000578107J3KSI2
ENSG00000134758ENST00000578914J3KRU4
ENSG00000134758ENST00000580499J3QKM8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
383095012024The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation.0
386665902024Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia.0
383095012024The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation.0
386665902024Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia.0
368002902023RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.5
368002902023RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.5
356976922022RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.6
360106362022The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.1
356976922022RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.6
360106362022The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.1
339078172021Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway.5
347590162021African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1.40
339078172021Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway.5
347590162021African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1.40
293716972018RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis.28

Citation

Dessen P

RNF138 (ring finger protein 138)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46877