Identity
HGNC
LOCATION
16q11.2
LOCUSID
ALIAS
CPR3,DJ3,DJA2,DNAJ,DNJ3,HIRIP4,PRO3015,RDJ2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10294
MIM: 611322
HGNC: 14884
Ensembl: ENSG00000069345
Variants:
dbSNP: 10294
ClinVar: 10294
TCGA: ENSG00000069345
COSMIC: DNAJA2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000069345 | ENST00000317089 | O60884 |
| ENSG00000069345 | ENST00000317089 | A0A024R6S1 |
| ENSG00000069345 | ENST00000563158 | I3L320 |
| ENSG00000069345 | ENST00000617000 | A0A087WT48 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Protein processing in endoplasmic reticulum | KEGG | ko04141 |
| Protein processing in endoplasmic reticulum | KEGG | hsa04141 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37640708 | 2023 | DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability. | 3 |
| 37670029 | 2023 | The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70. | 5 |
| 37640708 | 2023 | DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability. | 3 |
| 37670029 | 2023 | The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70. | 5 |
| 33229560 | 2020 | Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. | 29 |
| 33229560 | 2020 | Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. | 29 |
| 31395886 | 2019 | Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. | 31 |
| 31408507 | 2019 | Hsp70 and DNAJA2 limit CFTR levels through degradation. | 19 |
| 31395886 | 2019 | Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. | 31 |
| 31408507 | 2019 | Hsp70 and DNAJA2 limit CFTR levels through degradation. | 19 |
| 24318877 | 2014 | Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. | 81 |
| 24318877 | 2014 | Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. | 81 |
| 23091061 | 2012 | The DNAJA2 substrate release mechanism is essential for chaperone-mediated folding. | 26 |
| 23091061 | 2012 | The DNAJA2 substrate release mechanism is essential for chaperone-mediated folding. | 26 |
| 19940115 | 2010 | Hsp40 chaperones promote degradation of the HERG potassium channel. | 51 |
Citation
Dessen P
DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46879/dnaja2
