STAU1 (staufen double-stranded RNA binding protein 1)

2007-04-01  

Identity

HGNC
STAU1
LOCATION
20q13.13
LOCUSID
6780
ALIAS
PPP1R150,STAU
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6780
MIM: 601716
HGNC: 11370
Ensembl: ENSG00000124214

Variants:

dbSNP: 6780
ClinVar: 6780
TCGA: ENSG00000124214
COSMIC: STAU1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124214ENST00000340954O95793
ENSG00000124214ENST00000347458O95793
ENSG00000124214ENST00000360426O95793
ENSG00000124214ENST00000371792Q5JW30
ENSG00000124214ENST00000371802O95793
ENSG00000124214ENST00000371828O95793
ENSG00000124214ENST00000371856O95793
ENSG00000124214ENST00000437404Q5JW28
ENSG00000124214ENST00000456866F6UDC6
ENSG00000124214ENST00000614381A0A087X1A5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383477262024Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.0
389130262024Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.0
383477262024Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.0
389130262024Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.0
349907952022PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.3
358063492022Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.2
362328902022A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.1
349907952022PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.3
358063492022Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.2
362328902022A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.1
335412832021Distinct roles for the RNA-binding protein Staufen1 in prostate cancer.8
337451392021Staufen1 in Human Neurodegeneration.15
337623052021Noncanonical immune response to the inhibition of DNA methylation by Staufen1 via stabilization of endogenous retrovirus RNAs.19
338991582021Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells.6
341630322021NF-κB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay.12

Citation

Dessen P

STAU1 (staufen double-stranded RNA binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46907