ENO3 (enolase 3)

2007-04-01  

Identity

HGNC
ENO3
LOCATION
17p13.2
LOCUSID
2027
ALIAS
GSD13,MSE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2027
MIM: 131370
HGNC: 3354
Ensembl: ENSG00000108515

Variants:

dbSNP: 2027
ClinVar: 2027
TCGA: ENSG00000108515
COSMIC: ENO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108515ENST00000323997P13929
ENSG00000108515ENST00000518175P13929
ENSG00000108515ENST00000519266K7EP84
ENSG00000108515ENST00000519584P13929
ENSG00000108515ENST00000519602E5RGZ4
ENSG00000108515ENST00000520221K7EPM1
ENSG00000108515ENST00000521659E5RJH5
ENSG00000108515ENST00000521811E5RI09
ENSG00000108515ENST00000522249E5RG95
ENSG00000108515ENST00000522301K7EKN2
ENSG00000108515ENST00000522798E5RI09

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Glycolysis / GluconeogenesisKEGGhsa00010
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis, core module involving three-carbon compoundsKEGGhsa_M00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Glycolysis, core module involving three-carbon compoundsKEGGM00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
HIF-1 signaling pathwayKEGGhsa04066
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
GluconeogenesisREACTOMER-HSA-70263

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
354778212022ENO3 promotes colorectal cancer progression by enhancing cell glycolysis.6
354778212022ENO3 promotes colorectal cancer progression by enhancing cell glycolysis.6
316978742019Overexpression and Selective Anticancer Efficacy of ENO3 in STK11 Mutant Lung Cancers.23
316978742019Overexpression and Selective Anticancer Efficacy of ENO3 in STK11 Mutant Lung Cancers.23
259189392015A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA.7
259189392015A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA.7
252673392014Recurrent rhabdomyolysis due to muscle β-enolase deficiency: very rare or underestimated?13
252673392014Recurrent rhabdomyolysis due to muscle β-enolase deficiency: very rare or underestimated?13
213478382011Glycation of the muscle-specific enolase by reactive carbonyls: effect of temperature and the protection role of carnosine, pyridoxamine and phosphatidylserine.10
213478382011Glycation of the muscle-specific enolase by reactive carbonyls: effect of temperature and the protection role of carnosine, pyridoxamine and phosphatidylserine.10
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
194729182008Candidate-gene testing for orphan limb-girdle muscular dystrophies.6
194729182008Candidate-gene testing for orphan limb-girdle muscular dystrophies.6

Citation

Dessen P

ENO3 (enolase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46920/js/favicon/meetings/gene-fusions-explorer/