ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)

2007-04-01  

Identity

HGNC
ARIH1
LOCATION
15q24.1
LOCUSID
25820
ALIAS
ARI,HARI,HHARI,UBCH7BP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25820
MIM: 605624
HGNC: 689
Ensembl: ENSG00000166233

Variants:

dbSNP: 25820
ClinVar: 25820
TCGA: ENSG00000166233
COSMIC: ARIH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166233ENST00000379887Q9Y4X5
ENSG00000166233ENST00000561770H3BUS0
ENSG00000166233ENST00000562891A0A087WT96
ENSG00000166233ENST00000564062H3BNB9
ENSG00000166233ENST00000570085H3BSK4

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
338797672021ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.43
338797672021ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.43
305875762019Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.10
305875762019Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.10
296891972018Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.31
296891972018Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.31
285525752017Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.29
287903092017Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.31
289306812017Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells.125
285525752017Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.29
287903092017Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.31
289306812017Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells.125
256243492015The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.20
256243492015The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.20
230593692013Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies.18

Citation

Dessen P

ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46930/deep-insight-explorer/js/deep-insight-explorer/