FBXL12 (F-box and leucine rich repeat protein 12)

2007-04-01  

Identity

HGNC
FBXL12
LOCATION
19p13.2
LOCUSID
54850
ALIAS
Fbl12

Other Information

Locus ID:

NCBI: 54850
MIM: 609079
HGNC: 13611
Ensembl: ENSG00000127452

Variants:

dbSNP: 54850
ClinVar: 54850
TCGA: ENSG00000127452
COSMIC: FBXL12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127452ENST00000247977Q9NXK8
ENSG00000127452ENST00000585379Q9NXK8
ENSG00000127452ENST00000586073K7EK37
ENSG00000127452ENST00000586469K7EQJ7
ENSG00000127452ENST00000586651K7EPT3
ENSG00000127452ENST00000588922K7EQY7
ENSG00000127452ENST00000589438K7EPT3
ENSG00000127452ENST00000589626K7EIR3
ENSG00000127452ENST00000590277K7EPN7
ENSG00000127452ENST00000590808K7ELM5
ENSG00000127452ENST00000591009Q9NXK8
ENSG00000127452ENST00000592067K7EIK3
ENSG00000127452ENST00000592732K7ESL6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
375912422023FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress.0
375912422023FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress.0
272153842016SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical Ubiquitin Chain Synthesis.7
272153842016SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical Ubiquitin Chain Synthesis.7
261240792015FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.6
261240792015FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.6
237073882013Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.10
237073882013Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.10

Citation

Dessen P

FBXL12 (F-box and leucine rich repeat protein 12)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46954