Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9690
MIM: 614454
HGNC: 16803
Ensembl: ENSG00000009335
Variants:
dbSNP: 9690
ClinVar: 9690
TCGA: ENSG00000009335
COSMIC: UBE3C
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000009335 | ENST00000348165 | Q15386 |
| ENSG00000009335 | ENST00000389103 | Q15386 |
| ENSG00000009335 | ENST00000430750 | H7C0Y1 |
| ENSG00000009335 | ENST00000611269 | Q15386 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36380488 | 2023 | Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. | 2 |
| 36401616 | 2023 | Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome. | 2 |
| 36380488 | 2023 | Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. | 2 |
| 36401616 | 2023 | Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome. | 2 |
| 35840930 | 2022 | Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway. | 28 |
| 35840930 | 2022 | Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway. | 28 |
| 32930707 | 2021 | UBE3C promotes proliferation and inhibits apoptosis by activating the β-catenin signaling via degradation of AXIN1 in gastric cancer. | 9 |
| 33637724 | 2021 | VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism. | 26 |
| 32930707 | 2021 | UBE3C promotes proliferation and inhibits apoptosis by activating the β-catenin signaling via degradation of AXIN1 in gastric cancer. | 9 |
| 33637724 | 2021 | VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism. | 26 |
| 32039437 | 2020 | Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity. | 12 |
| 32039437 | 2020 | Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity. | 12 |
| 27003255 | 2019 | MiR-30a-5p/UBE3C axis regulates breast cancer cell proliferation and migration. | 21 |
| 30503554 | 2019 | Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex. | 32 |
| 27003255 | 2019 | MiR-30a-5p/UBE3C axis regulates breast cancer cell proliferation and migration. | 21 |
Citation
Dessen P
UBE3C (ubiquitin protein ligase E3C)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46959/ube3c
