GDF7 (growth differentiation factor 7)

2007-04-01  

Identity

HGNC
LOCATION
2p24.1
LOCUSID
ALIAS
BMP12

Other Information

Locus ID:

NCBI: 151449
MIM: 604651
HGNC: 4222
Ensembl: ENSG00000143869

Variants:

dbSNP: 151449
ClinVar: 151449
TCGA: ENSG00000143869
COSMIC: GDF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143869ENST00000272224Q7Z4P5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
Axon guidanceKEGGko04360
TGF-beta signaling pathwayKEGGhsa04350
Axon guidanceKEGGhsa04360
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390

References

Pubmed IDYearTitleCitations
377988092023Growth differentiation factor 7 autocrine signaling promotes hepatic progenitor cell expansion in liver fibrosis.0
377988092023Growth differentiation factor 7 autocrine signaling promotes hepatic progenitor cell expansion in liver fibrosis.0
333884172021TET-dependent GDF7 hypomethylation impairs aqueous humor outflow and serves as a potential therapeutic target in glaucoma.7
344082392021Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells.6
333884172021TET-dependent GDF7 hypomethylation impairs aqueous humor outflow and serves as a potential therapeutic target in glaucoma.7
344082392021Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells.6
282144722017Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties.22
282144722017Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties.22
267830832016The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.11
267830832016The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.11
254478512015Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.56
254478512015Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.56
241559672013BMP12 induces tenogenic differentiation of adipose-derived stromal cells.55
241559672013BMP12 induces tenogenic differentiation of adipose-derived stromal cells.55
217027182011Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.20

Citation

Dessen P

GDF7 (growth differentiation factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46990/gdf7