PPP4R2 (protein phosphatase 4 regulatory subunit 2)

2007-04-01  

Identity

HGNC
PPP4R2
LOCATION
3p13
LOCUSID
151987
ALIAS
PP4R2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 151987
MIM: 613822
HGNC: 18296
Ensembl: ENSG00000163605

Variants:

dbSNP: 151987
ClinVar: 151987
TCGA: ENSG00000163605
COSMIC: PPP4R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163605ENST00000356692Q9NY27
ENSG00000163605ENST00000460360H7C559
ENSG00000163605ENST00000476505F8WDK3
ENSG00000163605ENST00000482242F8WCA1
ENSG00000163605ENST00000488810C9IZ04
ENSG00000163605ENST00000495566C9IZF4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.25
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.25
225599362012PPP4R2 regulates neuronal cell differentiation and survival, functionally cooperating with SMN.10
225599362012PPP4R2 regulates neuronal cell differentiation and survival, functionally cooperating with SMN.10
201547052010A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.80
201547052010A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.80
186140452008A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.124
186140452008A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.124

Citation

Dessen P

PPP4R2 (protein phosphatase 4 regulatory subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46991/ppp4r2