HLF (hepatic leukemia factor)
1999-09-01 Franck Viguié AffiliationLaboratoire de Cytogenetique - Service dHematologie Biologique, Hopital Hotel-Dieu - 75181 Paris Cedex 04, France
DNA/RNA
DNA diagram
Transcription
3.9 kb
Proteins
Protein diagram
Description
295 amino acids, MW 43 kDa
Expression
HLF is normally expressed in hepatocytes and liver-derived cell lines, and, to a lesser extent, in lung, kidney and neurons of the central nervous system; it is not expressed in hematopoietic tissues or cell lines
Localisation
nuclear
Function
the normal function of HLF is largely unknown; HLF is a member of the PAR (proline and acidic amino acid-rich region) subfamily of b/ZIP (basic region leucine zipper) transcription factors; PAR and b/ZIP proteins bind to the DNA as dimers; HLF acts as a transcriptionnal transactivator; there are evidences that HLF protein transactivates factor VIII and factor IX genes, by binding as a homodimer (HLF/HLF) or a heterodimer with one albumin D-element binding protein sub unit (HLF/DBP), to multiple sites in the promoter of these genes; in the mouse central nervous system ontogeny, HLF expression increases markedly with synaptogenesis, suggesting that HLF plays a role in the function of adult differentiated neurons
Homology
other members of the b/ZIP PAR subfamily; in mammals: albumin D-element binding protein (DBP) and thyrotroph embryonic factor / vitellogenin gene binding protein (TEF/VBP); like HLF, they are transcription activators; the three proteins have an ability to form heterodimers with one another through the leucine-zipper domain; in other species : vitellogenin binding protein (VBP) in the chicken and Ces-2 gene in the nematode Caenorhabditis elegans
Implicated in
Entity name
Disease
childhood pro-B cell acute lymphoblastic leukemia
Prognosis
poor prognosis is likely
Fusion protein
fusion encodes a protein which contains the AD1 and AD2 transactivation domains of E2A, linked to the bZIP DNA binding / protein dimerization region of HLF
Oncogenesis
E2A-HLF alters the apoptotic pathway of pro-B lymphocytic cells, leading to the survival of defective cells that would normally be eliminated; it is to be noted that, in normal tissues, there is no evidence in favour of a role of native HLF in apoptosis regulation
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10073576 | 1999 | Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes. | Begbie M et al |
| 10023025 | 1999 | Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice. | Hitzler JK et al |
| 8608207 | 1996 | Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. | Hunger SP et al |
| 8639829 | 1996 | The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. | Hunger SP et al |
| 1386162 | 1992 | Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. | Inaba T et al |
| 9032268 | 1997 | Cell transformation mediated by homodimeric E2A-HLF transcription factors. | Inukai T et al |
| 9571207 | 1998 | Regulation of the DBP promoter by PAR proteins and in leukemic cells bearing an E2A/HLF translocation. | Newcombe K et al |
Other Information
Locus ID:
NCBI: 3131
MIM: 142385
HGNC: 4977
Ensembl: ENSG00000108924
Variants:
dbSNP: 3131
ClinVar: 3131
TCGA: ENSG00000108924
COSMIC: HLF
RNA/Proteins
Expression (GTEx)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36958694 | 2023 | m6A RNA methylation-mediated upregulation of HLF promotes intrahepatic cholangiocarcinoma progression by regulating the FZD4/β-catenin signaling pathway. | 6 |
| 37709768 | 2023 | HLF promotes ovarian cancer progression and chemoresistance via regulating Hippo signaling pathway. | 1 |
| 37712764 | 2023 | Tensin 1 regulated by hepatic leukemia factor represses the progression of prostate cancer. | 0 |
| 36958694 | 2023 | m6A RNA methylation-mediated upregulation of HLF promotes intrahepatic cholangiocarcinoma progression by regulating the FZD4/β-catenin signaling pathway. | 6 |
| 37709768 | 2023 | HLF promotes ovarian cancer progression and chemoresistance via regulating Hippo signaling pathway. | 1 |
| 37712764 | 2023 | Tensin 1 regulated by hepatic leukemia factor represses the progression of prostate cancer. | 0 |
| 34991659 | 2022 | HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk. | 60 |
| 36374958 | 2022 | CircCHD2/miR-200b-3p/HLF Axis Promotes Liver Cirrhosis. | 4 |
| 34991659 | 2022 | HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk. | 60 |
| 36374958 | 2022 | CircCHD2/miR-200b-3p/HLF Axis Promotes Liver Cirrhosis. | 4 |
| 33979320 | 2021 | Decreased HLF Expression Predicts Poor Survival in Lung Adenocarcinoma. | 12 |
| 34499717 | 2021 | HLF expression defines the human hematopoietic stem cell state. | 24 |
| 34876631 | 2021 | FLT3-ITD allelic ratio and HLF expression predict FLT3 inhibitor efficacy in adult AML. | 5 |
| 34925645 | 2021 | Integrative Molecular Analyses of an Individual Transcription Factor-Based Genomic Model for Lung Cancer Prognosis. | 2 |
| 33979320 | 2021 | Decreased HLF Expression Predicts Poor Survival in Lung Adenocarcinoma. | 12 |
Citation
Franck Viguié
HLF (hepatic leukemia factor)
Atlas Genet Cytogenet Oncol Haematol. 1999-09-01
Online version: http://atlasgeneticsoncology.org/gene/47/hlf
