Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55693
MIM: 609766
HGNC: 25498
Ensembl: ENSG00000186280
Variants:
dbSNP: 55693
ClinVar: 55693
TCGA: ENSG00000186280
COSMIC: KDM4D
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000186280 | ENST00000335080 | Q6B0I6 |
| ENSG00000186280 | ENST00000536741 | Q6B0I6 |
| ENSG00000186280 | ENST00000610872 | Q6B0I6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HDMs demethylate histones | REACTOME | R-HSA-3214842 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36579641 | 2023 | KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5. | 1 |
| 37828372 | 2023 | MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D Expression. | 0 |
| 36579641 | 2023 | KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5. | 1 |
| 37828372 | 2023 | MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D Expression. | 0 |
| 33434575 | 2021 | Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression. | 16 |
| 33434575 | 2021 | Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression. | 16 |
| 32094404 | 2020 | Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling. | 17 |
| 32754284 | 2020 | Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression. | 12 |
| 32989255 | 2020 | Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression. | 15 |
| 32094404 | 2020 | Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling. | 17 |
| 32754284 | 2020 | Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression. | 12 |
| 32989255 | 2020 | Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression. | 15 |
| 30527625 | 2019 | The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway. | 19 |
| 30527625 | 2019 | The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway. | 19 |
| 29599352 | 2018 | KDM4D Predicts Recurrence in Exocrine Pancreatic Cells of Resection Margins from Patients with Pancreatic Adenocarcinoma. | 6 |
Citation
Dessen P
KDM4D (lysine demethylase 4D)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47034/kdm4d
